Abstract
Childhood respiratory tract infections are serious and dangerous clinical
forms that occur around the world, and adenoviruses represent one of the
most significant viruses that cause these respiratory infections in children.
The three species B, C, and E of the adenovirus are mostly responsible for
these infections. In addition, rapid identification of adenoviruses is
absolutely necessary to prevent overuse of antibiotics in patients, prevent a
local epidemic of adenoviruses, and treat severe infections that may cause
serious and fatal disease. The current study was designed to detect the
prevalence of the adenovirus antibodies in children in Nasiriyah city, Iraq.
For this reason, the blood samples were collected from August 2022 to May
2023 from patients less than five years old who were hospitalized at the
Muhammad Al-Musawi and Bint Al-Huda hospitals. The samples were
obtained from fifty child infected with acute respiratory tract infection.
Concerning the children with immunocompromised, underlying illnesses
and persistent pulmonary abnormalities, they were prohibited. All
individuals were investigated for the detection of Adenovirus-IgM and IgG
antibodies using enzyme-linked immunosorbent assay (ELISA). The
adenovirus IgM antibodies were found in 9 percent of respiratory patients,
and the highest rate was found in males 24 (29.17%), compared to females 2
(7.69%), and the highest rate of IgM antibodies in the age group 1day–12
months was 58.33 percent. These results were statistically significant (p <
0.05). Higher rate of adenovirus IgG antibodies was found in 23 (46%) of
adenovirus patients, and the highest rate was found in males (66.67%) than
that in females (26.92%), and the highest rate of adenovirus IgG antibodies
in the age group 37–60 months was (64.0%), while the lowest rate in the age
groups 1–12 months was (8.33%). These results were statistically significant
(p < 0.05).
forms that occur around the world, and adenoviruses represent one of the
most significant viruses that cause these respiratory infections in children.
The three species B, C, and E of the adenovirus are mostly responsible for
these infections. In addition, rapid identification of adenoviruses is
absolutely necessary to prevent overuse of antibiotics in patients, prevent a
local epidemic of adenoviruses, and treat severe infections that may cause
serious and fatal disease. The current study was designed to detect the
prevalence of the adenovirus antibodies in children in Nasiriyah city, Iraq.
For this reason, the blood samples were collected from August 2022 to May
2023 from patients less than five years old who were hospitalized at the
Muhammad Al-Musawi and Bint Al-Huda hospitals. The samples were
obtained from fifty child infected with acute respiratory tract infection.
Concerning the children with immunocompromised, underlying illnesses
and persistent pulmonary abnormalities, they were prohibited. All
individuals were investigated for the detection of Adenovirus-IgM and IgG
antibodies using enzyme-linked immunosorbent assay (ELISA). The
adenovirus IgM antibodies were found in 9 percent of respiratory patients,
and the highest rate was found in males 24 (29.17%), compared to females 2
(7.69%), and the highest rate of IgM antibodies in the age group 1day–12
months was 58.33 percent. These results were statistically significant (p <
0.05). Higher rate of adenovirus IgG antibodies was found in 23 (46%) of
adenovirus patients, and the highest rate was found in males (66.67%) than
that in females (26.92%), and the highest rate of adenovirus IgG antibodies
in the age group 37–60 months was (64.0%), while the lowest rate in the age
groups 1–12 months was (8.33%). These results were statistically significant
(p < 0.05).
Keywords
Adenoviruses
ELISA
identification
Nasiriyah city
south of Iraq.