Thi-Qar Medical Journal

Background: Dacryocystorhinostomy is the surgical bypass of the lacrimal sac and duct for the treatment of
epiphora. Endonasal endoscopic dacryocystorhinostomy has been popularized as a minimally invasive
technique.
Objective: the study aims to highlight the endonasal endoscopic DCR
without stenting and to evaluate the results of the surgical procedure.
Patients and Method: This was a prospective study of 18 patients referred from the ophthalmology
department for dacryocystorhinostomy after having been diagnosed as distal obstruction of nasolacrimal
duct or sac. Data were collected through full history from the patients and clinical examination. Endoscopic
dacryocystorhinostomy was performed without stent between January 2019 and January 2020 in Al
Imamain Al Kadhimain Medical City and Al Qimma private hospital.
Results: The mean age was 34.83 years , range (12-53) years , 15 females(83.33%) and 3 males (16.67%) ,
10 right eyes(55.56%) and 8 left eyes(44.44%) . All patients presented with epiphora, 17 of them (94.44%)
presented with medial canthal discharge and 14 of them(77.78%) had medial canthal swelling with a mean
duration of symptoms of 8.72 (5.5-14) months. Four patients were sent for a CT scan. Five patients(27.78%)
had a septoplasty, two patients(11.11%) had conchoplasty to improve surgical access. The mean duration of
surgery was 39.99 minutes, no intraoperative complications, one patient(5.55%) developed granuloma at the
rhinostoma after 4 weeks and two patients(11.11%) developed synechia between the neo-ostium and middle
turbinate after 3-6 weeks and one patient(5.55%) had a recurrence after 12 weeks. The success rate was
94.44%.
Conclusions: The endoscopic endonasal DCR is a successful surgery with low serious complications for
treatment of distal nasolacrimal drainage obstruction if adequate sac exposure and good marsupialization are
performed.

Background:-.
Asthenozoospermia is one of the main causes of infertility or diminished fertility in men ,
Hyaluronic acid (HA) is a complex bioactive agent , which is fully represented in the female
reproductive tract. The oocyte of human being is enclosed by (HA), which acts as a physical
selector of spermatozoa. Human sperm cells that Assay
(HBA Score%) is an important
diagnostic tool for suspicious male infertility in the analysis of semen. In a matter of minutes ,
provides the mature binding spermatozoa in the sample .Direct swim-up technique is the oldest
and most frequently used activation technique.
To assess the sperm parameters and the percentage of binding spermatozoa to HA pre- and post
in vitro sperm activation for asthenozoospermic men.
Twenty –two asthenozoospermia men were collaborate in this study. Assessmet of sperm
parameters and HBA Score% pre- and post - direct swim up technique and the results were
statistically analyzed.
Significant increment (P-value<0.05) was noticed within progressive motility, morphology of
spermatozoa and a significant improvement in (HBA- Score) post - activation.

Summary
Background: Prostate cancer has few prognostic biomarkers, and differentiating between relapsing and
non-relapsing tumour can be challenging clinically.
Aims: This study aims to investigate the hypothesis that ALDH1A1 might be a potential biomarker for
prostate tumors and could distinguish between aggressive tumours requiring radical intervention and those
that have a good prognosis. It is thought to be a potential biomarker that can predict the clinical progression
and prognosis of different kinds of tumours. However, its role in prostate cancer remains unclear.
Materials and methods: ALDH1A1 expression has been evaluated by immunohistochemistry using 96
prostate tissue samples including normal, adjacent normal and cancer tissues.
Results: This study showed that ALDH1A1 was expressed in glandular and stromal regions of both benign
and malignant prostate tissues. Nuclear and cytoplasmic ALDH1A1 was increased significantly in
glandular regions of prostate cancer and was positively associated with increased tumor size. However,
stromal ALDH1A1 staining was not associated with prostate cancer and other parameters such as primary
Gleason grade and stage.
Conclusion: This preliminary data suggests that ALDH1A1 may have a role in cancer development and/or
aggressiveness and warrants further investigation to understand its function and establish if it could be a
potential diagnostic biomarker for prostate cancer.

Aim of the study
Because of high mortality [NMR]and the serious medical complications and bad prognosis among the neonates
whom born with LBW [specially the extremely LBW][1] and the costs to the family and society in keeping
LBW infants alive [ 2], so we conduct this study to determine some of maternal risk factors that associated with
neonatal low birth weight in order to reduce LBW morbidity rate in our locality.
Abstract
Objective: To determine the association of maternal medical, obstetric and social risk factors with neonatal
LBW.
Design: A descriptive study.
Place and time of study: This study was carried out in the department of neonatology in
teaching hospital during the period between January and May 2021.
Al- Habboby
Patients and methods: One hundred low birth weight (less than 2500mg) live born babies were taken
randomly to enrolled cases in this study our parameter is just the neonatal body weight, regarding maternal
medical, obstetric and social history taken from mothers.
Results: [66%] of cases were males and [34%] were females in ratio of Male to Female: 1.9:1.
Fifty-two percent [52%] were preterm (premature) and forty-eight [48%] were term [ small for date (IUGR) or
[SGA]. Also, the study found that forty-seven percent [47%] were delivered by cesarean section while fifty
three [53%] were by normal vaginal delivery.
The factors like maternal urinary and genital tract infection [88%], anemia [82%], exposure to cigarette
smoking [46%], low education [45%], bad psychological mode [35%], poor prenatal care [35%], hypertension
[20%], previous cesarian section [18%], poverty [13%] and diabetes mellitus [12%] have been considered as a
risk factor in causing neonatal LBW.
Conclusion
Common maternal risk factors for LBW neonates in AL Nasiriyah city include, GTI, anemia, cigarette smoking
exposure, worker pregnant, low education level, poor antenatal care, hypertension, DM and poverty.

Background: The lymphoid malignancies comprise one of the most diverse and heterogeneous sets of
diseases that exist under a single type of malignancy. In 2012, the American Cancer Society estimated there
were about 70,000 cases of non-Hodgkin lymphoma (NHL), and about 10,000 cases of Hodgkin lymphoma
in the United States, collectively accounting for about 4% to 5% of all cancers. The estimated number of
U.S.
cancer deaths attributed to lymphoma is about 3% for both males and females, ranking it about 8th among
all causes of cancer death. Hodgkin lymphoma typically carries a better prognosis, accounting for
approximately 1000 deaths per year. Whereas the lifetime risk of developing any cancer is about 1 in 2 for
males and 1 in 3 for females, the lifetime risk of developing non-Hodgkin lymphoma is about 1 in 43 and 1
in 51 for males and females, respectively (for the years between 2006 and 2008).
Since the discovery in 1964 of the Epstein–Barr virus (EBV) in African Burkitt lymphoma, this virus has
been associated with a remarkably diverse range of cancer types. Because EBV persists in the B cells of the
asymptomatic host, it can easily be envisaged how it contributes to the development of B-cell lymphomas.
However, EBV is also found in other cancers, including T-cell/natural killer cell lymphomas and several
epithelial malignancies. Explaining the etiological role of EBV is challenging, partly because the virus
probably contributes differently to each tumour and partly because the available disease models cannot
adequately recapitulate the subtle variations in the virus–host balance that exist between the different EBV
associated cancers .
Aim of the study:- To assess EBV over expression in lymphoma and its correlation with age , gender of
patients and type of lymphoma .
Materials and methods: this study was included 93 cases of archival lymphoid tissue, collected randomly
from the period of February 2015- April 2017 from Al-imam Al-hussein Teaching Hospital and some
private laboratories in Thi-Qar government . 41 patients of non Hodgkin’s lymphoma (NHL) and 52 patients
of Hodgkin’s lymphoma (HL) ,their median age 50.04 years range from (14–70 )years . A manual LSAB
procedure was used in the imunohistochemical (IHC) analysis (DakoCytomation Copenhagen ,Denmark)
and polymerase chain reaction (PCR) procedure was used in the molecular analysis (Bioneer company,
Korea).
Results: IHC analysis of EBV over expression was positive in (17.1%) of NHL and (42.3%) of HL , while
PCR analysis of EBV over expression was positive in (31.7%) of NHL and (61.5%) of HL were correlated
with age of patients and type of tumor,
Conclusion: These finding support the role of EBVs in carcinogenesis of lymphoma regarding behavior and
aggressiveness.

Summary
Background: Prostate cancer has few prognostic biomarkers, and differential diagnosis and
prognosis of aggressive versus non-aggressive tumors can be challenging clinically.
Aims: This study aims to investigate the hypothesis that NDRG1 might be a potential
biomarker for prostate tumor and could distinguish between aggressive tumors requiring
radical intervention and those that have a good prognosis. It is thought to be a potential
biomarker that can predict the clinical progression and prognosis of different kinds of tumors.
However, its role in prostate cancer remains unclear.
Materials and methods: NDRG1 expression has been evaluated by immunohistochemistry
using a tissue microarray cohort with 96 cases including normal, adjacent normal and
malignant prostate tissues.
Results: This study showed nuclear, cytoplasmic and membranous NDRG1 immunostaining
in both normal and malignant prostate tissues. Reduction of membranous and increased
nucleocytoplasmic NDRG1 staining is shown in prostate cancer compared to normal prostate
and is positively associated with increasing primary Gleason grade, but not with clinical
stage. Nuclear NDRG1 staining is increased significantly in prostate cancer and is positively
associated with increasing primary Gleason grade and clinical stage. In contrast, cytoplasmic
NDRG1 staining is decreased significantly in prostate cancer compared to normal prostate,
but not associated with other clinical features.
Conclusion: This preliminary data suggests that NDRG1 may have a role in cancer
development and/or aggressiveness and warrants further investigation to understand its
function and establish if it could be a potential diagnostic biomarker for prostate cancer.