Abstract
Background:
Coronavirus disease 2019 (COVID-19) is a widespread illness caused by the coronavirus 2 that
causes severe acute respiratory syndrome (SARS-CoV-2). We intend to investigate the clinical
characteristics and symptom status of SARS-CoV-2 patients.
Method:
We collected clinical data of 381 patients infected with SARS-CoV- 2 from early-June to mid
August 2020. Biological markers analyzed in this study include: PCRct value, CR-Protein, D
Dimer, LDL, and Troponin-I regarding the signs and symptoms for all patients enrolled in this
study.
Results:
Among 381 confirmed COVID-19 patients (166 males, 160 females), that divided into two
groups; 213 who received vaccination (single dose or booster mRNA vaccination), and 139
patients who did not receive vaccination. The significant differences were reported in the first
week and second week of infection for both vaccinated and unvaccinated patients that reported
for both cases (pv<.0001). Importantly, there were a significant differences reported in the
symptoms for both group in the first and second weeks of infection that were (pv=.0001). The
study reported that the D-Dimer was significantly elevated in both groups of the study, which
were (pv=<0.0001) for both group. While, there is no significant differences between the two
group that reported in the first and second week of infection with (pv=0.9974). Significantly,
CR-Protein in vaccinated COVID-19 cases was (pv=0.0001) similar to that of un-vaccinated
COVID-19 patients. Hence, the symptoms, Troponin, D-dimer, CRP level were higher in
COVID-19 patients in the second week during laboratory analysis including hospitalized
patients. Significantly, high LDL level in the second week and especially in female were
considerably reported in this study.
Conclusion:
Clinical markers have a crucial role in determining the prognosis for SARS-CoV-2 patients, and
vaccination effectiveness helped to reduce the severity of the virus's signs and symptoms.
Coronavirus disease 2019 (COVID-19) is a widespread illness caused by the coronavirus 2 that
causes severe acute respiratory syndrome (SARS-CoV-2). We intend to investigate the clinical
characteristics and symptom status of SARS-CoV-2 patients.
Method:
We collected clinical data of 381 patients infected with SARS-CoV- 2 from early-June to mid
August 2020. Biological markers analyzed in this study include: PCRct value, CR-Protein, D
Dimer, LDL, and Troponin-I regarding the signs and symptoms for all patients enrolled in this
study.
Results:
Among 381 confirmed COVID-19 patients (166 males, 160 females), that divided into two
groups; 213 who received vaccination (single dose or booster mRNA vaccination), and 139
patients who did not receive vaccination. The significant differences were reported in the first
week and second week of infection for both vaccinated and unvaccinated patients that reported
for both cases (pv<.0001). Importantly, there were a significant differences reported in the
symptoms for both group in the first and second weeks of infection that were (pv=.0001). The
study reported that the D-Dimer was significantly elevated in both groups of the study, which
were (pv=<0.0001) for both group. While, there is no significant differences between the two
group that reported in the first and second week of infection with (pv=0.9974). Significantly,
CR-Protein in vaccinated COVID-19 cases was (pv=0.0001) similar to that of un-vaccinated
COVID-19 patients. Hence, the symptoms, Troponin, D-dimer, CRP level were higher in
COVID-19 patients in the second week during laboratory analysis including hospitalized
patients. Significantly, high LDL level in the second week and especially in female were
considerably reported in this study.
Conclusion:
Clinical markers have a crucial role in determining the prognosis for SARS-CoV-2 patients, and
vaccination effectiveness helped to reduce the severity of the virus's signs and symptoms.
Keywords
Biological markers
Covid-19
D-dimer
Troponin-I
vaccination