Kufa Journal of Pharmaceutical Sciences

Aim of this study is to assess the knowledge, attitude and practice of the drugs using in patients with H.pylori infection
in Al-Najaf city. The Study Design: A descriptive cross-sectional study design was used in this study. It was conducted
in Najaf in accordance with the declaration and take information from individuals by both sheet and online
questionnaire. The questionnaire to collection of information about the belief of Najaf people regarding the H.pylori
infection, the survey was conducted during the period from 21 October to 23 November 2023.Data Collection: In this
study, total sample size are 202.The questionnaire used have four sections: sociodemographic characteristics such as age, gender, family history and previous history of H.pylori. Eleven questions in sheet questionnaire and sixteen
questions in online questionnaire about the knowledge of the participants about H.pylori infection and its management seven questionnaires about Attitude questions finally five questions in sheet questionnaire and eight questions in online questionnaire about practice questions. The results show the %population who suffered from burning pain in upper abdomen was (87.6 % ,79.59%) in the online questionnaire and sheet questionnaire respectively.Examination of breath test identified as one of a diagnosis way of H.Pylori by 61.22% in sheet questionnaire and 64.7% in online questionnaire.The percent about the patient don't have any signs and symptoms in current study was 68% in online questionnaire and 48.97% in face to face questionnaire.High knowledge in the current study was recorded about they will not stop taking the medication if there is an improvement in symptoms before complete the course of therapy where the percent was (96.2%) of participants.

Environmental and genetic factors are two of the many contributing factors to diabetes. Many studies
shows that the molecular processes of insulin resistance are connected to elevated oxidative and or inflammatory factors.The gut microbiota, combined with various environmental influences and predisposed genetic features, plays a part in the development of diabetes. Moreover, it has been suggested that changes in the gut microbiota can cause a mucosal immune response and increase intestinal permeability, both of which are factors in diabetes. Probiotics have been found to be an effective adjuvant in treatments for insulin resistance and may help maintain a better gut microbiota, the objective of the study is to assess the possible protective effect of probiotics on alloxan induced diabetes in male rat. Atotal of 18 matured Normoglycemic male Sprague Dawley rats, were randomly assigned in to 3 groups (6 in each group), Normal group receiving saline vehicle orally, Induced (Alloxane) group injected with alloxan (120 mg/kg i.p.) and Probiotic treated group treated with probiotics (2.5×10⁹ CFU, 160 mg) for 15 days before and 5 days after alloxan injection. Animals with fasting blood glucose levels >250 mg/dL consider diabetes. Blood samples were collected for biochemical analysis (e.g., glucose, insulin, oxidative stress markers). Data were analysed using ANOVA and Kruskal- Wallis tests, with significance set at p < 0.05. The results revealed significantly higher serum level of glucose, reduced insulin and c-peptide in alloxan induced diabetes rats compared to normal group. In addition, there are significant improvements in antioxidant system (SOD and GSH), a lower level of lipid peroxidation marker (MDA) as well as lower levels of serum concentration of urea and creatinine in probiotic-treated group. Probiotics may offer a promising therapeutic effect in improving diabetes complication and restore pancreatic B cell function, prevent cell distraction via gut microbiota modulation, restore intestinal permeability and decrease oxidative stress and markers of inflammation.

Isradipine is an antihypertensive agent that belongs to the biopharmaceutical classifications system (BCS) class 2,
suffering from low bioavailability due to its low aqueous solubility. The present work aimed to prepare Oro dispersible
tablets loaded with isradipine solid dispersion to achieve enhanced solubility and dissolution. Poloxamer 407 (PXM
407) in combination with the drug (PXM 407: isradipine) in (5:1) W/W% was used to prepare isradipine solid
dispersion using solvent evaporation method. The product was evaluated for percentage of yield, drug content, and
saturation solubility in phosphate buffer pH= 6.8. The produced solid dispersion mass was incorporated into
orodispersible tablets (ODTs) by direct compression method utilizing different types and ratios of diluents
(microcrystalline cellulose and mannitol) and superdisinegrants (croscarmellose and sodium starch glycolate). Five
orodispersible tablet formulas were prepared; subsequently, they were evaluated for weight variation, content
uniformity, hardness, friability, disintegration time, and dissolution testing. Formula number 2 (which composed of
30 mg of isradipine solid dispersion with microcrystalline cellulose and mannitol as diluents in addiction to 12%
croscarmellose as super disintegrant) demonstrated the shortest disintegration time, and it had a better release as
compared to pure isradipine -based orodispersible tablet.