Abstract
The Mannich reaction is one of the most important types of organic chemistry
fundamental reactions. It is a crucial stage in the production of various medicines,
natural goods, and industrial chemicals. Chemists' imaginations have always been
piqued because of this. In general, the Mannich reactions can be used as part of a
tandem reaction sequence to produce complex target molecules in an elegant and
often easy manner. The following article examines and summarizes methods for
synthesizing Mannich derivatives, in addition to offering a survey of recent
advancements in several fields’ applications of the Mannich reaction, such as
biological applications, antimicrobial activity, anticancer activity, anti-inflammation
and antioxidant activity, antimalarial activity, anti-viral activity, and so on. We also
go over how mannich base is used in industry and agriculture.
fundamental reactions. It is a crucial stage in the production of various medicines,
natural goods, and industrial chemicals. Chemists' imaginations have always been
piqued because of this. In general, the Mannich reactions can be used as part of a
tandem reaction sequence to produce complex target molecules in an elegant and
often easy manner. The following article examines and summarizes methods for
synthesizing Mannich derivatives, in addition to offering a survey of recent
advancements in several fields’ applications of the Mannich reaction, such as
biological applications, antimicrobial activity, anticancer activity, anti-inflammation
and antioxidant activity, antimalarial activity, anti-viral activity, and so on. We also
go over how mannich base is used in industry and agriculture.
Keywords
applications
biological activity
Mannich bases
synthesis