NTU Journal of Pure Sciences

Humen Respiratory Syncytial Virus (HRSV) causes acute respiratory tract infections in newborns and young children, which can result in serious consequences.. The aimof the study was to investigate the prevalence of HRSV in children below 5 years with respiratory infections and understand its correlations with demographic parameters. The studyinvolved 180 children with Respiratory tract infections aged between 2 months to 5 years. Serum specimens were collected and screened for HRSV IgM and IgG antibodies using enzyme-linked immunosorbent assay(ELISA) kits. TheResults showed that Humen respiratory synsycial virus IgM antibody found in 37(20.55%), with a significant correlation with age (P<0.05). While, Humen respiratory synsycial virusIgG antibody was positive in 29(16,11%) patients. , Humen respiratory synsycial virusIgM positivity was higher among children with allergies (72.97%), asthma (8.11%), bronchitis (18.92%). Also, children living in smoking environment had the highest positivity rate of IgM (62.16%) and IgG (62.07%). High IgM and IgG antibodies were recorded in patients with wheezing chest, and on mechanical ventilator P<0.05. In conclusion, the study demonstrate seroprevlance of HRSV infection in children with RTIs.

Vitamin B5 (pantothenic acid) was studied thermodynamically by calculating its conductivity parameters, like association constant Ka, equivalent conductance at infinite dilution Λₒ, ionic conductivity, and the main distance between ions in solution (R) at best-fit values of (ϬΛ). The values of Ka, Λₒ, and R were measured for equivalent conductivities in different solvents —water and methanol —at varying temperatures between 293 K and 313 K, as well as in mixtures of methanol and water containing 10%, 20%, 30%, 40%, and 50% methanol at 310 K. The experimental data were treated by the Lee-Wheaton conductivity equation of symmetrical electrolytes (1:1)and werefound be different from one solvent to another depending on the molecular interactions in the solution. Also, their physical parameters (viscosity & Dielectric constant) for each solvent were measured. Finally, thermodynamic quantities for the ion association reaction (∆G, ∆H and ∆S) have been studied. Density functional theory DFT calculations, (B3LYP/6-31g(d,p)) were employed to analyze vitamin B5 in the gas phase and diverse solvents. Three different continuity methods, namely AM1, PM3, and HF, were utilized, followed by DFT. The final method was applied to explore the effects on its characteristics.

Pseudomonas aeruginosa (P. aeruginosa) is a common nosocomial pathogenic bacterium found in hospitals and burn clinics and is a major cause of morbidity, and death. The current study aims to investigate the correlation among antibiotic resistance, pigment synthesis, and biofilm formation by P. aeruginosa. One hundred eighty samples were obtained from burn wounds at Azadi Teaching Hospitals/Burn Center. Only 48 isolates of P. aeruginosaare obtained from various sources of burns. A microtiter plate approach is used to detect biofilm formation. Results show that bacteria are most prevalent in flame burns, followed by hot liquid burns, gas explosions, and electrical burns, i.e., 41.7%, 35.4%, 16.7%, and 6.2%, respectively. Pyoverdine and pyocyanin are more frequently seen on cetrimide agar compared to other pigments. Antibiotic resistance rates vary across different antibiotics, such as Piperacillin (83.3%), Aztreonam (79.2%), Ceftazidimeand Cefepim (62.5%), and Amikacin (52.1%). Levofloxacin, Gentamicin, and Tobramycin show moderate resistance rates of 41.7%, 37.5%, and 35.4%, respectively; however, Imipenem and Ciprofloxacin exhibited minimal resistance and are considered the most effective against P. aeruginosa,and 33.3% of isolates are positive for ESBL. Biofilm formation is positive in 95.8% ofisolates, with 33.3% classified as strong producers, 45.8% as moderate producers, 16.7% as weak producers, and 4.2% as non-biofilm producers. An examination of the susceptibility test of biofilm-forming bacterial isolates reveals that 82.6% are multi-drugresistant (MDR). In conclusion, most P. aeruginosaisolates are potential biofilm producers and are significantly associated with antibiotic resistance. The development of multidrug resistance is found to be significantly correlated with pigment production.

The Electrical conductivity of N-(2-ChloroBenzylidene)-4-picolylamine was benchmarked in different solvents including water & methanol at temperature range of (293-313K) at 5Kintervals, and in (Methanol-Water) mixture at 298K in different percentage (10%, 20%, 30%, 40% and 50%). Then plotting the relation between equivalent conductivity (Ʌ) and square root of molar conc. (√Conc.). By using Kohlrausch equation the plot shows that the Schiff base compound act as weak electrolyte, i.e., weak association in water, methanol and (Methanol-Water) mixture. Then applying (Lee-Wheaton) equation for symmetrical electrolyte (1:1) to calculate different thermodynamic parameters including: Association constant (KA), equivalent conductivity at infinite dilution (Ʌₒ), main distance between ions (R), and Standard deviation (ϬΛ). The values of (∆H, ∆H, ∆S) were measured utilizing (Van’t-Hoff) equation. The final step including theoretical calculations to optimize the molecular energy of the compound and measuring different parameters in gas phase, water and methanol using (AM1, PM3) , HF, and DFT/B3LYP/6-31G.

Nanoparticles (NPs) constitute a main curiosity in the scientific community, as evidenced by a growing body of research that has revealed encouraging findings. Nano-oncology is a comparatively recent field of study that reveals new perspectives for cancer diagnosis and treatment. This technology can also play an essential role in targeting malignant cells. In this article, we showed the progressive development of the targeted, nanoparticle-based drug delivery system in the remedial application of pancreatic cancer. The treatment of pancreatic cancer (PC) remains a great challenge, as studies have shown that nanoparticles can be used alongside chemotherapy factors that further their effectiveness while decreasing their toxicity. Increasing the effectiveness of nanoparticle therapy may improve clinical outcomes in pancreatic cancer patients.Nanomaterials, particularly gold nanoparticles (AuNPs),have singular physicochemical characteristics, like tiny size, significant surface reactivity, big surface area to mass ratio, having surface plasmon resonance (SPR) sets, simple functionalization of surface and biocompatible, In this article, we will be discussing how the distinctive characteristics of AuNPs in the delivery of targeted medication for pancreatic cancer led to the surge efficiency of conventional chemotherapy for cancer-ill.

The problem of water pollution persists to this day. To reduce water pollution, which includes water produced from industrial units and wastewater, it had to be treated using several methods. This review focused on the use of adsorption technology, considered the most common method due to its ease of design and efficiency in removing pollutants. Recently, studies have shown that modifying red mud with chitosan can produce a new composite, RM/CS, as its efficiency in removing pollutants is good. This review summarizes previous studies conducted on the adsorption of heavy metal ions from aqueous solutions using the RM/CS component, comparing the maximum adsorption capacity qmax and removal with red mud activated by acidic or heat treatment, or both, and comparing it with the removal efficiency mediated by chitosan alone, studying the effect of the PH ,adsorption time apprised, and applying theLangmuir and Freundlich of the reaction isotherm to evaluate the efficiency of red mud modified with chitosan.