Samarra Journal of Pure and Applied Science

New octahedral complexes of (L1)N-(pyridin-2-yl)-1-(pyridin-4-yl)methanimine derived from (4-Pyridinecar boxaldehyde and 2-Aminopyridine) with the following metal ions Mn(II), Co(II), Ni(II), Cd(II), and Hg(II) were synthesized in ethanol. The ligand and its complexes are characterized by 1H NMR, FT-IR, 13C NMR, UV.Vis, chloride content, atomic absorption, magnetic susceptibility measurements, elemental microanalysis, thermal analysis, molar conductivity, mass spectroscopy, X-ray diffraction, dimensional measurements. Nanoparticles in the scanning electron microscope (SEM), which was used to characterize nanocomposites. After evaluating the antibacterial and antifungal properties of the compounds against two different types of bacteria (Gram-positive (G+) bacteria Staphylococcus aureus and Gram-negative (G-) bacteria Escherichia coli and one type of fungus (Candida albicans), the results indicated that the antibacterial activity The antimicrobial activity of the complexes is superior to that of the free compound. As for the biological activity of the nanocomposites, it indicates that the prepared complexes have the ability to inhibit the growth of Gram-positive and negative bacteria and Candida fungi in varying proportions, and that the biological activity of the prepared compounds has a greater inhibitory ability because they have nanoscale properties represented by an increase in the exposed surface area. Due to its interaction and small size, which makes it more effective than complexes and ligands.

Novel chalcones containing a carbazole ring were prepared through the condensation process between 9-ethyl-3-carbazolecarboxaldehyde and 2-acetyl-5-bromothiophene and 3-acetyl-2,5-dimethyl thiophene by the Claisen-Schmidt method, The compounds were identification using IR spectroscopy, 13C-NMR, and 1H-NMR techniques. The chalcones are highly effective against cancer cells, so three types of cancers were used, A-549 lung cancer, MCF-7 breast cancer, and HCT-116 colon cancer: Lung cancer, MCF-7: Breast cancer, Adenocarcinoma and HCT-116: Colorectal cancer, where we observed that chalcones are very effective against colon cancer cells and IC-50 was equal to 4. 5 μM for compound La, while compound Lb had an IC-50 of 0. 9 μM, and derivatives of chalcones, which are heterocyclic pyrazoline rings, were also synthesised using hydrazine and its derivatives, these compounds are also effective against cancer cells, and a comparison was carried out between chalcones and derivatives of these rings and it was found that chalcones are more effective against colon cancer cells, where the IC-50 of compound La1 was 66.5 μM and compound Lb3 was 27.6 μM, the IC-50 of compound La1 was equal to 66.5 μM.