Abstract
The adsorption of fexofenadine drug by activated charcoal powder impregnated
with hydrogen peroxide (IAC) to improve its surface properties was investigated.
The investigation also aimed to assess the effect of the repeated dose in increasing
the amount of the drug adsorbed. The powder activated charcoal was impregnated
with H2O2 3%. The effects of pH of the solution, concentration of the drug and time
of the reaction parameters were investigated by using UV-Vis spectroscopy. The
IAC was brought in contact with the drug solution in different pH (2, 4, 7 and 9),
drug concentrations (30, 60, 90 and 120 μg ml-1) and time (15, 30, 45 and 60
minutes). After each experiment, a repeated dose of IAC was introduced into the
solution and the adsorption process was repeated. The results showed that the
amounts of the drug adsorbed were decreased with increasing the pH and increased
with increasing the concentration of solution and time of contact. The adsorption
capacity was enhanced to about 70% after the addition of the repeated dose. The
study showed a spectrum displacement toward the blue region (blue shift) for the
drug supernatant in all experiment parameters, which was almost doubled when a
repeated dose was added.
with hydrogen peroxide (IAC) to improve its surface properties was investigated.
The investigation also aimed to assess the effect of the repeated dose in increasing
the amount of the drug adsorbed. The powder activated charcoal was impregnated
with H2O2 3%. The effects of pH of the solution, concentration of the drug and time
of the reaction parameters were investigated by using UV-Vis spectroscopy. The
IAC was brought in contact with the drug solution in different pH (2, 4, 7 and 9),
drug concentrations (30, 60, 90 and 120 μg ml-1) and time (15, 30, 45 and 60
minutes). After each experiment, a repeated dose of IAC was introduced into the
solution and the adsorption process was repeated. The results showed that the
amounts of the drug adsorbed were decreased with increasing the pH and increased
with increasing the concentration of solution and time of contact. The adsorption
capacity was enhanced to about 70% after the addition of the repeated dose. The
study showed a spectrum displacement toward the blue region (blue shift) for the
drug supernatant in all experiment parameters, which was almost doubled when a
repeated dose was added.
Keywords
Activated charcoal
Adsorption
Drug
Fexofenadine
Repeated dose.