Abstract
Hepatitis C Virus (HCV) causes about 70 million chronic infections, posing a serious threat to global health. This study aimed to determine the most common HCV genotypes and their effects on liver enzyme and hematological parameter concentrationsin Iraqi patients. This study examined 100 untreated HCV cases(infected Iraqi patients; age mean±SD: 41.99±16.78 years) and 100 uninfected HCV cases (control group; age mean±SD: 39.64±13.55 years). The study was conducted from January 2024 to October 2024 at Al-Yarmouk Teaching Hospital in Baghdad, Iraq Viral genotypes were determined by real-time PCR. Statistical analysis showed a significant increase in hematological parameters, with hemoglobin and PLT levels being significantly higher in infected patients compared to the control group (p<0.05). Similarly, liver enzymes were also increased in Iraqi patients infected with genotypes 1A and 4A of hepatitis C virus (HCV), Patients with the 4A genotype were older on average and showed a greater influence on laboratory parameters, possibly due to a weakened immune response associated with advanced age. In addition, Iraqi patients infected with HCV showed a higher prevalence of the 1A genotype (57%) compared to the 4A genotype (43%). This paper contributes to understanding the relationship between genotypes of HCV and changes in biochemical and hematological parameters by providing accurate information that helps in making evidence-based medical decisions that meet the patients' needs more accurately and effectively.
Keywords
1A genotype
2
3
4
4A genotype
5 and 6
and it’s global health issue
and the presence of hepatitis C virus antigen (HCV antigen) within the first six months following HCV infection [2]. The high rate of spontaneous mutation in RNA-enveloped viruses results in a varied collection of viruses with varying nucleotide sequences. Numerous subtypes
are among the six main genotypes. Small letters are used to indicate subtypes
AST) activity
Baghdad
causing significant liver damage to around 70 million people worldwide [1]. Indicators of acute viral hepatitis include jaundice
elevated serum alanine aminotransferase (ALT
hematological parameters
hepatitis C virus
including genotypes 1
including liver cirrhosis and hepatocellular carcinoma (HCC). It can lead to both acute and chronic hepatitis
IraqEmaildhuha.sabah@uomustansiriyah.edu.iq1.INTRODUCTIONHepatitis C Virus (HCV) is a blood-borne infection that can cause mild to severe disease
Liver enzymes.This is an open access article under the CC BYlicense.Corresponding Author:Dhuha Sabah HasanNational Center of Hematology
Mustansiriyah University
serum antibodies to HCV or RNA of HCV
such as genotypes 1a and 1b [3]. Genotypes of HCV and subtypes vary in their geographic distributions and correlations with demographic risk categories [4].