al-turath Medical Journal

Background: Human papillomavirus (HPV) infection is increasingly recognized as associated with endometrial immunological disturbance and adverse reproductive outcomes. Yet the systemic immunological and hormonal correlates of this association, and their diagnostic utility in clinical settings, remain poorly defined. Aim: This study aimed to assess the association of HPV infection with systemic immunological and oxidative stress markers and to evaluate their contribution to adverse pregnancy outcomes in women of reproductive age. Methods: A cross-sectional comparative study enrolled 120 women across four groups (n=30 each): Group 1 (HPV-negative controls), Group 2 (HPV-positive without complications), Group 3 (adverse pregnancy outcomes, HPV-negative), and Group 4 (HPV-positive with adverse pregnancy outcomes). Serum interleukin-6 (IL-6), interleukin-10 (IL-10), tumor necrosis factor-alpha (TNF-α), interferon-gamma (IFN-γ), peripheral blood natural killer (PB-NK) cells, malondialdehyde (MDA), superoxide dismutase (SOD), glutathione (GSH), progesterone, and estradiol were measured. Binary logistic regression and receiver operating characteristic (ROC) curve analyses were applied to identify independent predictors and diagnostic thresholds. Results: Group 4 showed the highest IL-6 (12.6±2.1 pg/mL), TNF-α (15.8±2.6 pg/mL), IFN-γ (17.2±3.1 pg/mL), and MDA (6.2±1.2 nmol/mL), with the lowest IL-10, PB-NK cells, SOD, GSH, progesterone, and endometrial thickness (p<0.001 to p=0.003). Logistic regression identified MDA (OR=3.06), TNF-α (OR=2.12), and IL-6 (OR=1.84) as significant independent predictors of adverse outcomes. ROC analysis revealed MDA as the strongest single diagnostic marker (AUC=0.891, cutoff ≥4.2 nmol/mL); the combined biomarker model achieved AUC=0.934. Conclusion: HPV infection is independently associated with systemic pro-inflammatory and oxidative stress dysregulation, hormonal insufficiency, and impaired endometrial receptivity. The MDA-TNF-α-IL-6 panel shows promising clinical utility for identifying women at elevated risk of pregnancy failure, warranting incorporation into preconception assessment protocols.

The expanding concerns regarding the safety of health care products used for oral disorders inspire the researcher to find alternatives that being safe and natural for oral care, this property was found it is way in searching the use of herbal products. The aim of the current research to formulate and evaluate herbal mouth was products using different herbs such as chamomile cinnamon, and clove. The prepared formulations were evaluated for physicochemical properties like organoleptic properties as taste and consistency, viscosity, and thermal stability. By agar diffusion procedure, the antibacterial efficacy of herbal mouth formulation was evaluated using an oral pathogen commonly encountered in pathogenesis of dental plaque. While radical scavenging technique was evaluated by using hydrogen peroxide to evaluate antioxidant activity of herbal mouth wash. The anti-inflammatory potential was assessed by the egg albumin denaturation method. The results elaborated that the best herbal mouth formulation has acceptable organoleptic that will satisfy consumer needs. The other properties were within acceptable ranges regarding pH, viscosity, and thermal stability. The antibacterial activity showed concentration-dependent inhibition for bacterial growth. Also, it showed better and significant antioxidant activity. The prepared herbal mouthwash formulation showed a potential regarding establishment of natural alternative for treatment oral health diseases.

Background Thalassemia is a heterogeneous group of genetic disorders caused by a deficiency in the production of beta chains of hemoglobin. Objective of this study was to determine the evaluating variables, measuring hematological, biochemical, and physiological indicators in beta-thalassemia patients and comparing the results with healthy individuals in carriers of beta thalassemia in Tikrit, Iraq. Patients and methods Fifty patients with beta thalassemia carriers who attended the laboratory department of Tikrit Hospital between August 2025 and February 2026 were included in this prospective cross-sectional study. Patients with microcytic hypochromic blood pictures underwent CBC testing, biochemical testing for T-protein, calcium, potassium, and ALP levels, as well as testing for serum iron and ferritin levels. Results: There were no statistically significant differences (p > 0.1) in the current study\'s sex-specific outcomes. The current study\'s findings on age groups revealed statistically significant differences (p < 0.02) across the study groups. At a probability level of p < 0.01, there are statistically significant variations in hematological parameters. Additionally, the two research groups\' total protein and potassium levels were found to be lower in patients than in healthy individuals, with statistically non-significant differences (p < 0.05). Serum iron and ferritin parameters showed statistically significant differences (p < 0.001) between the two study groups, although calcium and ALP levels showed statistically significant differences (p > 0.05) between patients and healthy individuals.