Abstract
The virus that causes a respiratory disease called coronavirus disease 19 (COVID-19). SARS-CoV2 is a member of a large family of viruses called coronaviruses. These viruses can infect people and
some animals. SARS-CoV-2 was first known to infect people in 2019. Patients with SARS-CoV-2
infection exhibit a range of systemic manifestations that correspond to an intense inflammatory
response and a cytokine storm, or rapid release of pro-inflammatory cytokines.This study aims to
estimate the serum levels of TNF-α and INF-γ among people in Baghdad after one month of
receiving the full Pfizer-BioNTech vaccine, SARS-CoV-2 virus infection, and SARS-CoV-2 virus
infection after Pfizer-BioNTech full vaccine respectively. A total of 120 individuals participated in
this study conducted at the College of Medicine / Iraqia University. They were divided into four
groups, each group containing 30 individuals. After one month, the study groups were categorized
into Pfizer-BioNTech (BNT162b2) full vaccination, infected with SARS-CoV-2, SARS-CoV-2
infection after full Pfizer vaccination, and control. The study showed a significant difference (P
value <0.05) in the TNF-α and INF-γ serum levels of all groups compared to the control and for
each group with each other except for the correlation between the infected non-vaccinated group
and the infected vaccinated group which shows a non-significant difference (P value >0.05).
Natural infection with SARS-CoV-2 with or without Pfizer-BioNTech vaccination can significantly
increase the titers of TNF-α and INF-γ in serum.
some animals. SARS-CoV-2 was first known to infect people in 2019. Patients with SARS-CoV-2
infection exhibit a range of systemic manifestations that correspond to an intense inflammatory
response and a cytokine storm, or rapid release of pro-inflammatory cytokines.This study aims to
estimate the serum levels of TNF-α and INF-γ among people in Baghdad after one month of
receiving the full Pfizer-BioNTech vaccine, SARS-CoV-2 virus infection, and SARS-CoV-2 virus
infection after Pfizer-BioNTech full vaccine respectively. A total of 120 individuals participated in
this study conducted at the College of Medicine / Iraqia University. They were divided into four
groups, each group containing 30 individuals. After one month, the study groups were categorized
into Pfizer-BioNTech (BNT162b2) full vaccination, infected with SARS-CoV-2, SARS-CoV-2
infection after full Pfizer vaccination, and control. The study showed a significant difference (P
value <0.05) in the TNF-α and INF-γ serum levels of all groups compared to the control and for
each group with each other except for the correlation between the infected non-vaccinated group
and the infected vaccinated group which shows a non-significant difference (P value >0.05).
Natural infection with SARS-CoV-2 with or without Pfizer-BioNTech vaccination can significantly
increase the titers of TNF-α and INF-γ in serum.
Keywords
COVID-19
SARS-CoV-2
Pfizer-BioNTech vaccine
Keywords
COVID-19
SARS-CoV-2
Pfizer-BioNTech vaccine