Muthanna Medical Journal

Periodontitis is a chronic inflammation that effect the tissue that surround and support the
teeth, and this is prevalent cause of teeth loss in adults while prostatitis is a comparatively
common issue affecting about 12 percent of men, and it’s the most common prostate-related
health issue in men under age fifty. Researches showed that the heart diseases spread in the
persons that have periodontitis about 25-50% higher than healthy persons. Recent studies
have connected periodontal disease with plenty of systemic health risks, including heart
disease and prostatitis but their results were varied. The recent study aimed to explore the
linking of gum diseases with heart diseases and prostate inflammations. In total, 150 serum
samples of four age groups of participants distributed as 100 (66.7%) samples of patients with
periodontitis and other 50 (33.3%) samples of control, All patients were attending to Ibn alBitar hospital, teaching laboratories – Medical city and Specialized Dental Center \ AL-Alwiya
and the diagnosis of all cases based up on patients medical history that evaluated by qualified
physicians and some other laboratory investigations. As (38.0%) patients with heart diseases
history and (58.6%) patients with prostatitis. Sample were analyzed for Triglycerides, Prostatespecific antigen (PSA) and CRP levels. The abnormal Triglycerides level estimated by
(37.3%), while the elevated level of (PSA) was determined by (40.0%). Furthermore, the
prevalence of CRP seropositivity in individuals increased by (43.3%). The incidence of
periodontal disease (PD) was paralleled with the positivity of tested biochemical markers of
cardiovascular disease (CVD) history and prostatitis respectively with high significant
differences (P= 0.000). Finally, there is significant connection of PD with CVD and prostatitis,
but further studies are needed, and the outcomes of this study have limitations, also the
current finding encourages to review a large sample size with different age groups in order to
clarify this issue.

The cause of breast cancer remain unknown, but numerous factors have been directly associated with increased risk of breast cancer incidence. Among them lipid profile is one of the most important risk factors that may directly associate with breast cancer prevalence and incidence. The objective of this study is to assess lipids profile parameters in women with breast tumor and investigate their role in breast tumor initiations. A case control study was done on105 women range from 35 -70 years that had breast tumor. Lipids profile parameters were measured in serum of women who were categorized as newly diagnosed with untreated malignant breast tumor (n=35), newly diagnosed untreated women with benign breast tumor (n=35) and comparable age healthy women that considered as a control group (n=35). There were significant increases in the levels of TC and LDL-C in patients with malignant tumor in comparison with both benign group and controls, while TG and VLDL levels were significantly elevated in patients with malignant breast tumor in comparison only with control group. Receiver Operating Characteristic (ROC) curve showed that TC and LDL-C levels showed high sensitivity and specificity with high area under curve in malignant condition. In conclusions, lipids profile parameters especially TC and LDL-C may have a direct role in breast cancer initiation, progression and metastasis.

The placenta is a temporary organ required for the development of embryo and fetus. It allows the physiological exchange between the fetus and the mother. Endothelin is a human protein has three isoforms, endothelin-1, -2, and -3. Endothelin-1 (ET- 1) is the most potent and long lasting vasoconstrictor known. Endothelin has two receptors, ETA and ETB, ETA receptors are found on the external surface of the vascular smooth muscle cells of blood vessels, and binding of endothelin to ETA increases vasoconstriction.Objectives: To study the histochemical distribution of vasoactive agent (endothelin -1) in placental tissue after normal vaginal delivery and elective caesarean section, this might be a determinant of the onset of parturition. The current study includes studying forty two placentas (21NVD&21CS) with an eccentric cord insertion were obtained from a healthy pregnant female (with no hypertension, diabetes mellitus, or gynecological diseases or any other major diseases). The placental tissues were histologically prepared for paraffin sections. Staining procedure includes histochemical stain for endotheline-1 using goat polyclonal IgG antibody against endothelin-1 as primary antibody and biolinylated as secondary antibody. An immunostaining score according to the graduated intensities of the reaction product was defined and scored blindly by two investigators who scored Staining intensity (-, +, ++, +++, ++++). The median intensity of ET-1 was highest in placenta delivered by normal vaginal delivery (++++) and lowest in those by cesarean section (+). The normal vaginal delivery group of placentas was associated with statistically significant higher median ET-1 stain intensity compared to that of cesarean section group. In-conclusion: ET-1 activity in placental tissue is significantly higher in normal vaginal delivery group.