Abstract
Background: Total antioxidant status(TAO), superoxide dismutase (SOD) and Catalase (CAT) are
antioxidant defensive enzymes that are catalyze the reduction of reactive oxygen species (ROS) to non
harmful substance. Aim: The study focuses on the serum super oxide dismutase enzyme level, CAT level and
total antioxidant status in colorectal cancer patients, which result due to an imbalance between aggressive
and defensive factors. Materials and Methods: the study included 40 patients and 20 healthy individuals for
comparative analysis were considered for the present study. (TAO), serum (SOD) and (CAT) levels of each
individual were performed. Results: Statistical analysis of serum antioxidant enzymes level and antioxidant
status revealed a significant increase in SOD, CAT of patients group (p.≥0.05), and (P.≥0.01) respectively.
The TAO was significant increase (p.≥0.001). The increasing preponderance of serum SOD, CAT levels
and the TAO can be explained on the basis of alteration on enzymes activity, which may lead to disturbance
in homeostasis of antioxidant/oxidant balance... Conclusions: TAO, Catalase and Superoxide dismutase
enzyme used a biomarker of enzymatic alteration in different diseases including cancer.
antioxidant defensive enzymes that are catalyze the reduction of reactive oxygen species (ROS) to non
harmful substance. Aim: The study focuses on the serum super oxide dismutase enzyme level, CAT level and
total antioxidant status in colorectal cancer patients, which result due to an imbalance between aggressive
and defensive factors. Materials and Methods: the study included 40 patients and 20 healthy individuals for
comparative analysis were considered for the present study. (TAO), serum (SOD) and (CAT) levels of each
individual were performed. Results: Statistical analysis of serum antioxidant enzymes level and antioxidant
status revealed a significant increase in SOD, CAT of patients group (p.≥0.05), and (P.≥0.01) respectively.
The TAO was significant increase (p.≥0.001). The increasing preponderance of serum SOD, CAT levels
and the TAO can be explained on the basis of alteration on enzymes activity, which may lead to disturbance
in homeostasis of antioxidant/oxidant balance... Conclusions: TAO, Catalase and Superoxide dismutase
enzyme used a biomarker of enzymatic alteration in different diseases including cancer.
Keywords
Catalase
Colorectal Cancer
Reactive Oxygen Species
Superoxide Dismutase
Total Antioxidant Status