Al-Kitab Journal for Pure Sciences

The aim of the study is to evaluate the seroprevalence of human herpes virus type 8 (HHV-8) in women with breast cancer. The study has been conduct in Kirkuk city for the period from January 1, 2019 to April 1, 2019 on 50 breast cancer women with age group 21-70 years. The study has also included 40 healthy women as control group. The study included the collection of 3 ml of venous blood for identification and measurement of IgG antibodies towards the HHV-8 by using ELISA technique (KomaBiotech, Co, USA). The study also included taking of full information from cases like living situation, age. The study showed that the maximum frequency of HHV-8 infection (34%) recorded among breast cancer women comparing with the control group (10%), with highly significant relation. The majority of breast cancer women with positive IgG were within the age group 51-60 (41.18%) and the lowest rate was in the age group 21-3 years. The study showed that the maximum frequency of HHV-8 infection in breast cancer women was found in women with 2nd stage of breast cancer (58.83%) and the lowest rate was in the 1st stage. The highest rate of HHV-8 infection in breast cancer women (76.47%) were with metastasis to neighbor lymph nodes while compared with 23.53% without metastasis while all breast\t cancer women with HHV-8 negative were without metastasis. It has concluded that there was significant association between HHV-8 infection and occurrence of breast cancer and high rate of this infection has related to metastasis.