JOURNAL OF KUFA FOR CHEMICAL SCIENCES

Metabolic syndrome is the medical term for a cluster of metabolic abnormalities that increases in individuals risk of diabetic mellitus type 2 ( T2DM ) and cardiovascular diseases(CVD)._ENREF_1 The components of MS are glucose intolerance, obesity, hypertension and dyslipidemia.An insulin resistance is the key phase of metabolic syndrome constitutes the major risk factor for the development of diabetes mellitus.

The New Heterocyclic ligand 4-[(2,4,6-trioxohexahydropyrimidin-5-yl)diazenyl]benzoic acid (L) was prepared to give the final Didentate Heterocyclic compound with different donor atom system. The Prepared ligand was characterized using FTIR, 1H-NMR, C.H.N. Elemental analysis and UV.-Vis. techniques.
Some chelating metal complexes were Prepared with Co (II), Ni(II) and Cu(II) ions and characterized by FTIR, UV.-Vis. ,Molar conductance, C.H.N. Elemental analysis and magnetic susceptibility. The Purity of azo dye ligand and prepare complexes were tested by Thin – Layer Chromatography (TLC) Technique . The complexes were found to have the general formula [M(L)2Cl2] where M= Co (II), Ni(II) and Cu(II) . The FTIR results demonstrated that the coordination site were the azo Nitrogen atom and Oxygen atom of Carbonyl group of the azo ligand . The electronic spectral and magnetic measurement data indicated that the complexes exhibited octahedral geometry were suggested for there complexes, (M:L) ratio was (1:2) for all prepared complexes while the conductivity measurements shows non – electrical properties.

Metabolic syndrome is the medical term for a cluster of metabolic abnormalities that increases in individuals risk of diabetic mellitus type 2 ( T2DM ) and cardiovascular diseases(CVD)._ENREF_1 The components of MS are glucose intolerance, obesity, hypertension and dyslipidemia.An insulin resistance is the key phase of metabolic syndrome constitutes the major risk factor for the development of diabetes mellitus.

Metal ion Mn+2 as homogeneous catalyst has been used in the oxidation of alanine in acid medium. The reaction shows first order kinetics with respect to Ce(IV), the reactions also showedfraction order kinetics with respect to Mn+2 and alanine and inverse first order with respect to [H+]. The reaction product (Cerium(III) Sulphate (Ce2(SO4)3) was added to the reactions and had no effect on the rate of oxidation of alanine by Ce(IV). Changing ionic strength, dielectric constant and chloride ion of the medium has no effect on the rate of oxidation. Ce+2 and Mn+2have been suggested to be the reactive species. A reaction mechanism was suggested and rate law had been derived . Aldehyde have been identified to be the oxidation products of the reaction

Anew azo–Schiff base ligand(4-((E)-(3-iodophenyl)diazenyl)-2-((3-(trifluromethyl) phenyl imino)methyl) phenol (IFPMP) was prepaered by condensation of ((E)2-hydroxy-5-((3-iodophenyl) diazenyl) benzaldehyde with 3- (trifluromethyl)aniline .This azo-azomethine ligand was reacted with some transition metal ions such as Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II) and Zn(II) forming seven chelate complexes . The structural features have been arrived from their C.H.N elemental analysis ,FT-IR , UV-Vis , 1HNMR , Mass spectra, magnetic moment measurement and molar conductance. The data show that complexes have the composition of [M(L)2(H2O)2] for all chelate complexes except of Cr(III) and Fe(III) which were found that the composition as [M(L)2Cl(H2O)] .Based on this data we propose octahedral geometry for all metal complexes. The influence of the prepared new ligand and its chelate complex on the corrosion inhibition of carbon steel in (0.5M) HCl solution was studied by weight loss. Results show that maximum inhibition efficiency of 47.8% is afforded by the studied concentration of the ligand (4ppm) at 298K , while the maximum inhibition efficiency of its ligand complex is 29.5% by (20ppm) at 298K from weight loss method measurements.

This research involves preparation of heterocyclic compounds from indole -2- carboxylic acid. The first step synthesized of ester compound from indole -2- carboxylic acid and prepared hydrazinamide from ester.Then prepared Schiff bases from hydrazinamide derivatives with benzaldehyde derivatives. The last step preparedoxazepine and oxazepane derivatives from Schiff bases with(malice, phthalic and succinic)inhydride .These compounds were characterized by melting point ,FT.IR,1HNMRand13C-NMRKey words: indole -2- carboxylic acid,Schiff bases,Oxazepine , 1,3-oxazepane, biological activity.

The study Included synthesis of some new azetidinone ring Derivatives from prepared Azo Compound [4-Amino-3--((4-methoxy-2-nitrophenyl)diazenyl)-N-(Pyrimidine-2-yl)benzen-esulfonamide](N1) by the reaction of it with p-amino acetophenone " to give the Schiff base (I). From the imine group and free aromatic amine group in the Schiff base (I), a derivative containing seven and four rings was prepared in several steps.Most of these derivatives were confirmed by "FT-IR,1HNMR and 13CNMR" spectra.

Schiff base derived from (3-thiophene carboxyaldehyde with p-amino aniline, and 4-N, N-diethyl aniline) has been prepared and characterized by Infrared and, and C.H.N. elemental analysis. Results of the in vitro antibacterial activity showed that the N-[(thiophene-3-yl) methylidene]-4 (N, N diethylamino) benzene (compound A) was found to be more active than N-[(thiophene-3-yl) methylidene] -4-nitrobenzene (compound B) against most pathogenic bacterial strain for both of Gram-positive bacteria, Staphylococcus aureus and Gram-negative bacteria, such as E. coli under study. Some of these compounds showed potential antimicrobial activities. In addition, the electrical conductivity of new Schiff bases was characterized; new Schiff bases were showed high electrical conductivity and that increase of ability to prepare anew-organic diodes.

The present work included synthesis of novel (azo-shiff) via compounds in high yield, which react with (4-amino phenol , 3-nitro anilin and 4- methyl anilin) condensation reaction to produce various heterocycles (Five membered) ring like (Imidazolidine and tetrazole).The strcture of the newly synthesized compounds were monitored by (TLC) and identified by many techniques (FTIR , 1HNMR and C13NMR) and melting points.