Al-Mustansiriyah Journal of Science

Klebsiella pneumoniae is a member of coliform bacteria that causes wide ranges of infections including circulatory, respiratory system, urinary tract infections (UTIs), and wounds infections. This study aimed to find the correlation between type 1 and 3 fimbrial genes expression with multidrug resistance (MDR) K. pneumoniaeisolates towards antibiotics. Sixty clinical isolates of K. pneumoniaewere collected from three main types of samples including blood, wound and burn swabs, and urine samples. The diagnosis was confirmed by VITEK-2 system and 16s rRNAhousekeeping gene. The antibiotic sensitivity profile included 16 antimicrobial agents, with extended-spectrum beta-lactamase production. PCR technique was applied to detect four genes of type-1 fimbrial genes: (usher-1, chaperon-1L, chaperon-1S,and fim-H1), beside type-3 fimbrial genes: (MrkA, MrkB, MrkC, MrkD,and MrkF). The results showed that K. pneumoniaeisolates were hundred percent (100%) resistant towards ampicillin, no resistance (0%) was recorded towards tigecycline and ertapenem, while the percentages of resistance for ceftazidem, cefepime, amikacine, and amipenem were 15%, 20%, 51.7%, and 50% respectively, and the isolates showed about (13-71%) resistance to the rest antimicrobials agents. The production of extended-spectrum beta-lactamase was in 40 (66.67%) of total the 60 isolates. There was no relationship according to the statistical analysis between the typesof specimen with the antibiotic resistance rates. For fimbriae type 1 genes, the largest occurrence (90%) was reported in Chaperon-1Sgene and the lowest one was in Usher-1gene (56.6%), while it was above 70% in Chaperon-1Lgene and fim-H1gene of the total K. pneumoniaeisolates. The percentages of type 3 genes MrkA, MrkB, MrkC, MrkD,and MrkFwere: 28.3, 76.6, 85, 51.6, and 63.3% respectively. The type-1 fimbrial genes had no significant correlation among them;however, the type-3 fimbrial genes had significance in their presence at 0.01 and 0.05 levels,as they are located on the same Mrk operon. Finally, the correlation between type 1 and 3 fimbrial genes with the type of specimen and antibiotic resistance was not significant at all.

Patients with Multiple sclerosis (MS) are presented with different degree of disability based on Expanded disability status scale (EDSS). Several studies reported that ABH non-secretors have higher prevalence in different auto-immune diseases, also platelets have a multi-form participation in development of MS. Therefore, this study aimed to assess the correlation of clinical manifestations in patients with platelet-activating factor (PAF), P-Selectin, matrix metalloproteinase-9 (MMP-9) and ABH secretor status. Fifty Iraqi patients with relapsing-remitting multiple sclerosis (RRMS) were enrolled and divided into two subgroups; 36 of them with no disability (D0), their EDSS score ranging between 0-1.5, and the rest 14 patients with different degrees of disability (D+), their EDSS score ≥ 2. Along with patients, 20 healthy subjects were involved to act as a control group. Results showed significant elevation of PAF, P-Selectin, and MMP-9 levels in patients compared with those in the control group. However, only PAF level in D+ patients is significantly higher than D0 and positively correlated with duration of disease and serum level of MMP-9. Moreover, the frequency of non-secretors among RRMS patients is significantly higher than those in the control group and have a higher level of MMP-9, so may act as a risk factor for getting MS disease via increasing the serum level of MMP-9

In this research paper, we focus on designing and developing a fully automated gene regulation from cancerous cell heterogeneity using advanced machine learning techniques. There are several modern technologies developed to make DNA sequencing easier and cheaper. Among them, gene regulation produces the longest read sequences and the lengths of the reads are growing day by day. Machine learning technique like Support Vector Machine (SVM) is developed to align these gene sequences. Every technique faced some challenges, but facing the desired challenges introduce some new challenges on the other side. So, no one tool is perfect for every work. The SVM technique is a new aligner tool that does a tradeoff and performs better from different aspects. For the model with the best generator loss, an average maximum validation accuracy of 91.29% was achieved. The gene regulation with SVM is like a mini-map that takes a few times more memory to index the whole genome of a reference sequence. The single-cell data are the main target of SVM. It is shown that it would help the SVM and similar techniques to align better with long insertions and deletions of single-cell gene regulation. Single-cell data is run against the well-known reference sequence and a randomly generated synthetic reference

In this paper, we proposed new techniques to solve one of the important fields of the Combinatorial Optimization Problem, which is the problem of machine scheduling. The problem which wants to be solved in this paper is the total tardiness times and range of lateness. For bi-criteria we have (1//(∑????????,????????))while for bi-objective we have (1//(∑????????+????????)). In order to solve the suggested two problems, some new exact and approximation methods are suggested which are produced good results. The results whichare obtained from applying the newly proposed methods are compared with the exact method; like Complete Enumeration Method (CEM), then compared results of the heuristics with each other\'s to obtain the most efficient method

In this work, new kindsofseparation axioms using wpopen sets, some results, properties, examples, and the relationship between these concepts have been given to support our work

In this paper, we introduce the region and the faces poset of shiarrangement that it was firstly introduced by J.-Y. Shi. This isan affine arrangement,each of whose hyperplane is parallel to some"hyperplane of Coxeter arrangement"(Braid arrangement), the degrees and the exponents of this arrangement were found and we prove the shi arrangement is ahyperfactored arrangement when n=3 and not hyperfactored arrangement when n=4 arrangemen

The aim of this research is to partition ????????(3,11)into orbitsusing the subgroups of ????????????(4,11)which are determined by the nontrivial positive divisors of the order of ????????(3,11). These orbits were also studied from the perspective of arcs by finding complete and incomplete arcs

In this study, we propose multi-objective functions which consist of the sum of completion time, tardiness time and earliness time where Cidenoted the completion time of job (i), Ti=max{Ci-di,0}, denotes the tardiness of job (i), Ei=max{di-Ci,0}be denoted the earliness of job (i).This problem is defined by ????2//∑∑(????????????+????????????+????????????)????????2????=1.In this paper, we will present some theoretical analysis discussion, and prove when we have a problem with scheduling n jobs on two identical parallel machines (IPMSP)

In this work, we introduce some common fixed pointstheorems type rational contractions on generalized Banach space. The provided theorem is a generalization and an extension of many well-known theorems; we present a few examples to illustrate the validity of the results obtained in the paper

In this paper, we have relied on the dominant control system as an important toolin building the group of leaders because it allows leaders to contain less dense areas, avoid local areas and produce a more compact and diverse Pareto front. Nine standard nonlinear functions yielded this result. MaBAT/R2 appears to be more efficient than MOEAD, NSGAII, MPSOD and SPEA2. MATLAB was used to generate all the results of the proposed method and other methods in the same field of work

Using the AIRES code and three hadronic interaction models, a simulation study of the energy of created particles due to the development of an extensive air shower was carried out (EPOS-LHC, QGSJET-II-04, and Sibyll2.3c). The main focus is put on theenergy of the create particles as a function of depth for (12C,56Fe, p, and 28Si) primary particles with high primary energies (1017,1018,1019, and 1020) eV with two zenith angles 0°and 30°. The New parameters were obtained by fitting the energy of created particles curves using Gaussian and linear functions for created particles, initiated by primary particles at the energy 1020eV. Good agreement was obtained by comparing the present results with results simulated by CORSIKA simulation for primary proton at the energy 1019eV

This work investigated the development of magnetic and optical properties and the invention of a previously unused lens. Manynewdesigns have been suggested for a unipolar magnetic lens based on changing the width of the inner bore and fixing the other geometrical parameters of the lens to improvethe performance of unipolar magnetic lenses. The investigation of a study of each design included the calculation of its axial magnetic field the magnetization of the lens in addition to the magnetic flux densityusing Finite Element Method(FEM). Itwas found that the best magnetizing properties, the highest value of magnetic flux and the lowest value of bandwidthof the axial magnetic field strength have been obtained when thewidth of the inner cavity was(55 mm). The effect of current density on the optical properties has been also studied, and it was found that the optical properties have been improved also, and the chromatic and spherical aberration values havedecreased significantly. Thus,thelens (55 mm)was chosen as the best design among the proposed designs.

Several innovative designs were designed for magnetic lenses, a bipolar lens with innovative and different geometric shapes, where the outer Inner pole side of the iron shroud, which is symbolized by the symbol (L), was changed. 2,4,6 A/mm2) and after it was designed, the engineering parameters were studied in terms of magnetic properties, i.e.,calculating the magnetic flux density with different current densities, and then studying the optical properties in terms of spherical aberration as well as chromatic aberration. Which made slight changes to the magnetic and optical properties of the bipolar lens and led to an improvement in the performance of the lens because the resolving power increased its amount when the change was made, as well as the aberration where both spherical aberration and chromatic aberration decreased

In this paper, tungsten oxide thin films weresynthesizedsuccessfully by the laser pulse deposition (PLD) method using a pulsed laser (ND-YAG) and wavelength (1064 nm) on a glass substrate at different laser fluencies. The effectof increasing laser fluencyon the optical and structural properties of WO3 nanoparticle thin filmswereinvestigated by UV-Visible spectrophotometer, X-Ray diffraction (XRD), atomic force microscope (AFM) and Scanning Electron Microscope (SEM). X-Ray measurements for all samples of WO3NPs thin films have shown that by increasing the laser fluencies from 5.175 to 6.369 J/cm2, the intensity of the (201) diffraction peak increases due to the film continuing to grow with increased crystallization.

The research aims to study the effect of radiation emitted from different clinical sources, including cobalt and strontium. The study was carried out using isolates of Pseudomonas bacteria isolated from Baghdad hospitals during the year 2021, about 20 isolates from the blood of patients infected with the bacteria. The results showed a lethal effect on Pseudomonas bacteria when exposed to radiation at different times during one hour, two hours and three hours. Different doses using cobalt with effective 1 mci and 10 mci in the presence and absence of aluminium, and the use of strontium in the presence and absence of aluminium. Co60(10Mci) without Aluminium, with dose 12.48472106(1hr.), 24.96944212 (2hr.), 37.45416318 (3hr.) that emit Beta and Gamma; Co60(10Mci) with aluminium with dose 0.023315312×10-7(1hr.), 0.046630625×10-7(2hr.), 0.069945936×10-7(3hr.) that emit Beta ray; Co60(1Mci) without Aluminium with dose 3.4178394 (1hr.), 6.835678887 (2hr.), 10.2535182 (3hr.) that emit Beta and Gamma; Co60(1Mci) with aluminium with dose 0.155992856*10-4 (1hr.), 0.311985712*10-4 (2hr.), 0.467978568×10-4(3hr.) that emit Beta ray and Sr90 with dose 0.73251×10-2(1hr.) 1.4650×10-2(2hr.), 2.19753×10-2(3hr.) The results showed that the killing rate of P. aeruginosabacteria using cobalt 10 mCiwithout aluminium was 78%, and in the presence of aluminium 100%. In comparison, the killing rate of Pseudomonas bacteria with effective effectiveness of 1 mC without aluminium was 100% and in the presence of aluminium 98%, and the killing rate of Pseudomonas bacteria without aluminium was 83% and in the presence of aluminium 96% compared with control