Iraqi National Journal Of Chemistry

H-point standard addition method (HPSAM) has been applied to the
simultaneous spectrophotometric determination of mesalasine (5-ASA) and isoniazid
(INH) drugs in binary mixtures. The method is based on the Schiff\\\\\\\\'s base formation
of drugs with 1,2-naphoquinone sulphonate (NQS) as a chromogenic reagent in the
presence of micellar cityltrimethyl ammonium bromide (CTAB) and sodium
carbonate. The results showed that simultaneous determinations could be performed
with the ratios 0.4:1.4 and 1.6:0.2 measured at pair of wavelengths (438 and 521 nm)
with recovery % range 94.5-105 % and precision better than 2.95 %

A simple, accurate, economical, and rapid spectrophotometric method for the determination of isopropamide iodide in pharmaceutical preparation (tablets) has been developed. The method is based on the reaction of isopropamide iodide and sodium nitrite in sulfuric acid medium to form iodine which shows maximum absorbance at 449 nm. Beer,s law was obeyed in the concentration range ) 20-240μg/ml). The molar absorptivity and Sandell,s sensitivity of the colored complex are 0.67×103 l/mol.cm. and 0.717 ng/cm2 respectively .The limits of detection and quantization are 5.8 and 17.4 μg/ml respectively. The analytical parameters were optimized and the method was successfully applied to the determination of isopropamide iodide in pure form and its tablets form.

Background and aim: β-thalassemia major is an autosomal recessive disease that leads to a severe hemolytic anemia in early infancy. Study of the oxidative stress in sera and saliva of homozygous β-thalassemia major patients is the aim of the present study.
Materials and methods: Serum and saliva specimens were collected from 91 males, 51 cases were β-thalassemia major patients, aged 11 to 26 years (mean= 15.275 ± 4.4501 years) and 40 were age- and gender-matched healthy controls.
Results: The results for the serum specimen showed a highly significant decrease (P<0.001) in total antioxidant status (TAS), and a highly significant increase (P<0.001) in ferric reducing capacity (FRC), total oxidant status (TOS), and oxidative index (OSI) in all studied patients compared with that of control group. While in saliva specimen, a non-significant decrease (P>0.05) in TAS with a non-significant increase (P>0.05) in FRC while a significant increase (P<0.05) in both TOS and OSI in the patients compared with that of control group.
Conclusion: The following can be concluded based on the results of the current study: the measured oxidative stress in Iraqi thalassemia patients due to the increase in FRC and the decrease in TAS. Furthermore, saliva can be used as an alternative fluid instead of serum for measurement of FRC in β-thalassemia major patients.

The study included the study of the preparation of activated carbon from coconut shell with different bitumen's material by adding salicylic acid at constant ratio's with Potassium hydroxide. The ratios of reactive substances, The amount of reactants carbonated material and bitumen's material were verified using different ratio's to obtain a better Production which is not less efficient than some other types.to obtain a better result of iodine number adsorption and methylene blue pigment adsorption,It had to be done the physical and chemical tests of the prepared models, including determination of the density, ash, iodine (IN),measure mentexternal surface area by the method of adsorption of the Methylene Blue aqueous, measurement Humidity content.