Iraqi National Journal Of Chemistry

The current study was conducted on 90 women divided into three groups: G1 included 30 women with breast cancer, and G2 included 30 women with breast cancer that received a single dose of treatment and 30 women as the control group (healthy), the ages of the groups ranged between (27-25) years, as the samples were collected from the Oncology Hospital of the Medical City in Baghdad Governorate, for the period between 1/11/2022 to 1/2/ 2023. Where about 5 ml of blood was collected from the blood of the groups of patients as well as from healthy women and the samples were divided based on the type of test, after placing them in jell tubes free of anticoagulant and leaving the blood at a temperature of 25 ° C until it coagulates and then placed in a centrifuge for 10 minutes at a speed of 3000 cycles/minute and then the serum was obtained and then placed in Eppendorf and kept in deep freezer at a temperature of -20 ° C for the purpose of Measure the levels of CA15-3 urea and creatinine in s with breast cancer women.The results of the current research showed a significant increase in the cancer antigen CA15-3 in the serum of G1 and G2, compared to the control group with a significant decrease in the G2 group compared to G1, while urea and creatinine showed a significant increase in the serum of G2compared to G1 and healthy women

A novel spectrophotometric technique has been introduced for quantifying minuscule quantities of the anticancer drug vincristine sulfate (VCS). This approach is based on the combination of vincristine sulfate with 4-chloroaniline. The resulting dye displays a molar absorptivity of 1.47×104 l.mol-1. cm-1 at its peak absorption wavelength of 455 nm. The method adheres to Beer's law over a range of 10-300 μg of vincristine in 10 ml (equivalent to 1.0 – 30 ppm) and exhibits low detection limits (LOD) of 0.12 μg/ml and quantification limits (LOQ) of 0.40 μg/ml. The color reaction remains highly stable and maintains its absorbance without significant deviation (within acceptable analytical error) for up to 24 hours, demonstrating a relative error between +0.37 to +1.02% and a relative standard deviation ranging from ±0.42 to ±1.05%, depending on the concentration level. This method has been effectively utilized for quantifying vincristine sulfate in pharmaceutical formulations

Recently, lemon juice has been extensively explored as a cheap, easily available, non-toxic, biodegradable, usable, reusable, highly selective, biocatalyst, and green solvent in organic synthesis, especially nitrogen-containing heterocyclic compounds. a simple, conventional, green, and environmentally friendly one-pot procedure for modification N-substituted 1,2,4-triazole (1) using lemon juice as a renewable and natural catalyst via click multicomponent reaction among glycine, thiosemicarbazide, and vanillin has been successfully done. This supreme unite building is used later as an active precursor, usually through the Biginelli reaction as a click three-component reaction with dimedone and substituted benzaldehyde in acidic media from lemon juice too to afford poly fused heterocyclic compounds (2-7). The available spectral and elemental analysis (FT-IR, 1H-NMR, GC-Mass, and CHN) confirmed the synthesized compound's structure. In contrast, the biological activity as an anti-lung cancer agent has been evaluated only for compound (3), and the results were impressive.

This research includes the synthesis of a number of new complexes of some transition elements such as Co(II), Ni(II), Cu(II) and non-transition elements Zn(II), Cd(II), Hg(II) with the ligands of Schiff bases resulting from the condensation reaction between Salicylaldehyde and 3-amino-2-phenylquinazolin-4(3H)-one.
The ligand and its complexes were studied and diagnosed through molar electrical conductivity, magnetic susceptibility measurements, electronic spectra, infrared spectra, proton nuclear magnetic resonance spectroscopy, gas chromatography-mass spectrometry, and biological activity of the ligand and some of its complexes has been studied. It was shown through the study that the ligand gives neutral, non-electrolytic complexes that have the chemical formula [M(HBAPQ)Cl2] and [Co(HBAPQ)2)Cl2] as:
M = Ni(II),Cu(II), Zn(II),Cd(II),Hg(II)
HBAPQ = (E)-3-((2-hydroxybenzylidene)amino)-2-Phenylquinazolin-4(3H)-one
The values of the electronic spectra and magnetic susceptibility measurements showed that the prepared complexes were tetracoordinate tetrahedral geometry, except for the cobalt (II) complex, which was hexacoordinate octahedral geometry.