Abstract
Protective effect of (Andrographis Paniculata) on 4-Vinylcyclohexene Diepoxide.A group of 55
female albino rats undergo experiment on the outcome effect of 4-vinylcyclohexene Diepoxide
injection for a priod of two weeks, as well as treatment effect of methanolic leaf extract of
Andrographis paniculata oral administration for four weeks. Injection concentrations (160 and
320mg/kg. B.W) also two different doses of treatment (100 and 200mg/kg. B.W) have been
applied.The results on body weight and ovary weight were more evident when higher
concentration dose was applied. Whereas, both induced dose were effective and no significant
difference was recorded. Histological examination of ovary induced clearly the effect in various
ovary tissues, and accumulation of connective tissue collagen fibers around corpus luteum where
as a higher dose of treatment found to be behind sign of re-normalizing the within four weeks of
treatment. More detailed study proposed to findout the exact right dose for treatment and may the
further study extend to include other medicinal plant that might be more efficient.
female albino rats undergo experiment on the outcome effect of 4-vinylcyclohexene Diepoxide
injection for a priod of two weeks, as well as treatment effect of methanolic leaf extract of
Andrographis paniculata oral administration for four weeks. Injection concentrations (160 and
320mg/kg. B.W) also two different doses of treatment (100 and 200mg/kg. B.W) have been
applied.The results on body weight and ovary weight were more evident when higher
concentration dose was applied. Whereas, both induced dose were effective and no significant
difference was recorded. Histological examination of ovary induced clearly the effect in various
ovary tissues, and accumulation of connective tissue collagen fibers around corpus luteum where
as a higher dose of treatment found to be behind sign of re-normalizing the within four weeks of
treatment. More detailed study proposed to findout the exact right dose for treatment and may the
further study extend to include other medicinal plant that might be more efficient.
Keywords
4-Vinylcyclohexene Diepoxide(VCD)
Andrographis Paniculata Leaf
Ovarian Toxicity
Rats.