Thi-Qar Medical Journal

SUMMARY
Background: The development of new blood vessels is essential to embryonic growth
and throughout life for physiological repair processes. Tumors cannot enlarge beyond 1-2
mmindiameter or thickness unless they are vascularized. Angiogenesis is an essential
step in growth of primary tumor and for distant metastasis. MVD (Microvessel Density)
is one of the important measurement to asses angiogenesis.
Aim: The aims of this study are to asses the micro vessel density (MVD) of
endometrium using two markers which are (CD31 and CD34),to investigate the
relationship between the degree of angiogenesis and clinicopathological variants, to
determine its usefulness in histopathological practice, and to compare between the two
markers.
Materials and methods: This retrospective study includes formalin fixed, paraffin
embedded tissue sections from patients underwent different gynecological diagnostic and
therapeutic procedures. These samples were taken from the hospitals in the period between
August 2005 and January 2007. forty nine cases were studied; 10 were normal functional
endometrium; 21 hyperplasia, and 18 were diagnosed as endometrial carcinoma. Five
slides for each case was done, one slide was stained with Hematoxylin and eosin (H&E),
and re-examined to confirm the diagnosis, and the other four were stained
immunohistochemically for monoclonal antibodies CD31 and CD34 (two slides for each
one).

Background :Hypertensionwith high pulse pressure causesmore arterial damage
comparedtohighbloodpressurewithnormalpulsepressure.
Objective:Thisisacrosssectiondescriptivestudycarriedout toexploretheefficacyof
different antihypertensive therapies using the pulse pressure as a predictor of better
responseandshowtheassociationsbetweenantihypertensivemedicationclass and the
magnitudeofpulsepressureamongpersonsreceivingtreatmentforhypertension.
Patients andmethods: 921 hypertensive patients on different antihypertension
medicationclasseswhoattendingAnNasiriyah GeneralHospital out patients over 6
months are examined todetermined their pulse pressure and compared the results of
differentgroupsaccordingtoageofthepatientsandantihypertensionmedicationclasses.
Results:hypertensivesubjectswhouseddiureticsaloneor incombinationwithbeta
blockershadlowermeanpulsepressureascomparedwiththoseusingotheragentsand
thisfindingissoclearandstaticallysignificantamongpatientsolder than60withnosex
difference.

Objectives : This study is aimed to alert the neurosurgeon about significant of the burr
hole plus D. X. T. in median survival in treatment of the deep-seated malignant brain
tumor (highly malignant astrocytoma) .
Methods : Throughout a period of 5 years– 50 cases which were proved and diagnosed
by brain CT scan , brain MRI and histopathological examination as cases of deep-seated
malignant brain tumor " malignant glioma , Astrocytoma Grade III , IV " I divided these
50 cases into 2 groups , the 1st group was 25 cases which was treated by burr-hole biopsy
plus deep X. therapy while 2nd group was treated by formal , classical craniotomy flap
with subtotal excision of the tumor plus deep . X. therapy all the cases were operated Al
Kadhimyah Teaching Hospital , Al-Mosawy private hospital and Al-Saady Hospital in the
Al-Basra city .
Result : We found there is no wide difference between these two neurosurgical methods
in relation to the median survival in treatment of the deep-seated malignant brain tumor .
Conclusion : The use of surgical technique of a burr hole plus D.X.T indicated the need
for the use of the steriostatic surgery , therefore that a burr-hole plus D. X. T is to be
recommended as a usual method of neurosurgery to treat a deep-seated malignant brain
tumor " Astrocytoma Grade III , IV .

Atotal of 662samplesof urineandvaginal discharge fromwomenwithandwithout
symptoms forTrichomoniasis (STD)wereexaminedduring theperiodfromSeptember
2007toFebruary2009whoenteredtheMaternityandpediatricshospital ,privateclinic
andlaboratories ineachBasrahandThiqarProvince(SouthernIraq)usingTVK3/7gene
as target byPCR technique. The results shows that the urine samples has 90%of
sensitivitytodetect theparasiteand thatmean thepossibilityofuse theurine todetect
infectionwithtrichomoniasisbyPCRasuseofvaginaldischarge,suggestingthaturinary
tractgetinfectioninrate90%duringinfectionofvagina.

SUMMARY
The present study investigated the relationship between blood parameters and oxidant
antioxidant parameters of patients with unstable angina pectoris and myocardial infraction in
Thi-Qar province / south of Iraq.. The results showed a significant elevation for each one of
WBCs count, absolute neutrophil value and ESR in patients with unstable angina(UA) and
myocardial infraction(AMI) when compared with control. Also a significant decrease was
observed for each one of RBCs count, PCV, and Hb in both patient groups compared with
control. The results of biochemical parameters explained a significant increase of
malondialdehyde(MDA) and ceruloplasmin(Cp) in patients with UM and AMI compared with
control group. Creatin phosphokinase(CPK) and lactate dehydrogenase(LDH) had a
significant rising in patients with AMI , while there was a slight and non significant rising for
both enzymes in patients with UM compared with control group. Albumin was decreased
significantly in blood serum of AMI patients , while albumin level was not effected in blood
serum of UA patients compared with control. Also, the results indicated the positive
relationship between MDA and ESR,WBCs,absolute neutrophil value and ceruloplasmin in
UA patient group , while in AMI patient group , the MDA was positively correlated with
ESR,WBCs,absolute neutrophil value,ceruloplasmin ,CPK and LDH.In addition, the was a
negative relationship between MDA and albumin in AMI patients.

Background: Tamoxifen is widely used to treat breast carcinoma in postmenopausal
women. Previous studies have suggested an increased prevalence of endometrial carcinoma
and polyps after treatment with tamoxifen.
Objective: This study was performed to evaluate pelvic sonographic measurement of
endometrial thickness in postmenopausal breast cancer patients being treated with tamoxifen
during one year and after 2year of treatment and its accuracy.
Patients and method: Pelvic ultrasounds and medical records were reviewed for 48
postmenopausal women with breast carcinoma who were being treated with 20mg of
tamoxifen. They were divided into two groups first group (28 patients)of at minimum 6
month and maximum 1 year treatment and second group (20 patients) of 2 years at minimum
treatment with tamoxifen. Endometrial thickness was measured in anteroposterior dimension
and was considered normal when less than 6 mm.
Results: pelvic sonograms of all 48 patients showed that 25(52%) of women with normal
endometrial thickness measuring less than 6mm in the two groups with 18 (64.3%) in first
group and 7(35%) in second group and abnormal endometrial thickening measuring more
than 6 mm in the two groups about 23 patients (48%) with 10(35.7%) in first group and 13
(65%) in second group in which the sonographic appearance of the endometrium included
cystic lesion in 2 patient(15.4%) and 11 patient (84.6%) without cystic lesion.
Conclusion: Only pelvic ultrasounds were done for endometrial evalution and the late
complication are increased because of poor investigations being done to those patients in
Basrah with breast carcinoma. A positive pelvic ultrasound result is of little value, so further
testing is mandatory in order to detect benign and malignant endometrial disease associated
with tamoxifen.

The present measured the ultrasonographic parameters of the pelvicalyceal system in
dyspeptic individuals (263), and another (168) males and (158) females patients who have
been diagnosed as cases of acute appendicitis (AA). Samples of their appendices’ and
peritoneal fluid were taken for histopathological, microbial and immunological studies. The
white blood cell count (WBC) and general urine exam (GUE) were estimated for all subjects,
which were used in this study prior to appendectomy.This study revealed that (34%) of the
patients , were accompanied by right pelvicalyceal system dilatation (RPCSD), (1.5%)
effected bilateral pelvicalyceal system dilatation (PCSD,) preoperatively and continued for
three to four weeks, post operatively, but all of the cases followed up; restored normal
pelvicalyceal system (PCS) later to the appendectomy.

Migraine is one of the common varieties of headache .The objective of the present study on
41 patients(16 males and 25 females) were attending the emergency department in Qurna
hospital ,Basrah direction during the period 5/2008-11/2008 and 30 healthy (11male and 19
female) control of similar ages (15-≥50),body mass index (BMI ;mean 25.0 kg/m2.rang 24.7
31.89 kg/m2).Magnesium levels in serum and whole blood were studied during the onset of
headache in each 41 patients .Twenty-five of 41 (61%) were female 9(56%), 16(64%), with
and without aura respectively, and 16 (39%) were male that 7(44%), 9(36%) with and without
aura respectively. Twenty five (61%)of cases where between 31and 45 years old .In this age
rang 14(56%)were female and 11(69%) male. Serum and whole blood magnesium levels in
patients were significantly lower than control (p≤0.01),.In amultiple linear regression model
with age ,BMI, and smoking status as covariables (p≤0.01).

This work involves preparation many compounds from cyclization of amino acid (Alanin,
Argenine and Aspartic acid) by acetic an hydride to give (1-3) compounds, the last react with
hydrazine to give its derivatives 1-amino-1- H–imidazol 5(4H) one. Schiff’s bases was
prepared from react (4-6) compound with various aldehydes and ketones ethyl bromo acetate
react with (4-6) will be prepare (15-17) which react with hydrazine to give hydrazide
derivatives (18-20) which condensation with aldehyde to keton to form Schiff’s bases (21
25).on the other side compounds (15-17) react with thiosemicarbazide to obtain (26-28) which
convert to (24-30) by deal with H2SO4 and to (31-33) by react with Sodium hydroxide.