Iraqi National Journal Of Chemistry

Prostate cancer is an important and potentially fatal disease in humans. Both genetic and environmental risk factors are associated with increased risk of prostate cancer among Asian populations. Previous observations have shown that heavy metals play various roles in human health. The heavy metals such as copper and zinc are known to be associated with prostate cancer, but their functions are unclear. The aim of the present work was to study serum trace elements such as Cu and Zn in Iraqi male patients with prostate cancer. A total of 25 prostate cancer patients was participated in this study from the Al-Kadhimia Teaching Hospital; their age range was (40–65) years and 25 healthy men matched in age as a control group during the period from February 2015 until the August 2015 after the diagnosis using a histopathological examination of the malignant tumor, the blood was centrifuged and serum samples resultant were separated and stored until the assay time. There was a significant increase in serum copper in prostate cancer patients as compared to the control, (P=0.001) while serum levels of zinc showed no significant differences, (P=0.42). However, there was an elevation in serum zinc levels in prostate cancer patients as compared to the control, but it was not statistically significant. The copper/zinc ratio was increased in prostate cancer patients as compared to the control, but it was not significant, (P=0.42). This study had shown a significant increase in copper value, no significant difference in zinc value, and higher copper/zinc ratio in malignant prostate. The Cu/ Zn ratio was found to be a better indicator of grade of prostate cancer.

Quantitative Structure–Property Relationship (QSPR) models based on molecular descriptors derived from molecular structures have been used for the prediction for computed the dielectric constant (ε) of pentane substituted. QSPR model includes some Molecular descriptors, regression quality indicates that these descriptors provide valuable information and have significant role in the assessment of the dielectric constant of compounds understudy. four QSPR equation for the prediction of dielectric constant have been drawn up by using the multiple regression technique. (Eqs 1-4) with the values of R2 range from 0.862-0.969, Ra2 range from 0.702-0.923, Q2 range from 0.86-0.93 and the values of S range from 0.989-0.488, while the values of F range from 75.127-172.796. The results show excellent model by Eq 3. with high of R2, Ra2, F and minimum S by using five parameters [D.M and T.E], was found and indicate that these parameters have important role in determining the properties of dielectric constant . this result encourages the application of QSPR to a wider selection of compounds properties and to other classes of compounds, including industrial, biopolymers.

Two new thiadiaza- and triaza-crown ethers on n-dodecyl mannopyranoside have been synthesized and characterized by proton, carbon NMR, high resolution mass spectrometry CHN analysis and FTIR. The antibacterial activities of synthesized macrocycles and their analogues was performed against two gram-negative and two gram-positive bacteria in two cultural media.

A simple , rapid, sensitive and new spectrophotometric method to estimate zinc in pharmaceutical preparations is described. The method depends on the reaction between zinc and the new synthesized reagent [4,5-diphenyl-2-((1E)-(4-(1-(2henylhydrazono)ethyl)phenyl)diazenyl)-4H-imidazole] (DPHEDPI ) to form a reddish-pink complex at pH 7.5 with a mole ratio (M:L)of (1:2), the complex exhibits a maximum absorbance at 520 nm with molar absorptivity coefficient (Ɛ) of 4.4*10 2L.mol-1 cm-1. Beer’s law is obeyed in the range of (0.5–27) ppm for zinc with correlation coefficient of (0.9996) ,and the stability constant was found to be 1*10 12L.mol -1. The relative standard deviation for seven replicate measurements, relative error and recovery values of this method were found to be 0.0015 % , -0.778%, and 99.22% respectively. Finally, this proposed method was applied for the determination of zinc in the zinc sulphate capsules drug and the results were compared with atomic absorption method.

In this study the adsorption of cefixime on to selected Iraqi clay bentonite. The aim of this study is to search for selective active surface in adsorption of the drug and to act as physical antidotes in treatment of poisoning if the drug is taken in quantities higher than the recommended dosages. Quantitative estimation of the drug adsorption has been done by utilizing the technique of UV spectrophotometry in λmax (273) nm at different conditions of temperature (25, 37, 45) ˚C found the adsorption decrease with increase the temperature. Study of clay weight of bentonite (0.1-1.5) gm found the adsorption increase with increase of clay weight, study effect of pH (1.2, 3, 5, 7) on adsorption of bentonite found the optimum adsorption at (pH = 5). Finally effect of ionic strength on adsorption used NaCl solution (0.1-0.3) M found decrease with increase of ionic strength. The results of adsorption isotherms fitted with freundlich isotherm.