Iraqi National Journal Of Chemistry

Condensation of (S)-2-(N-((2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)pentanamido)-3-methylbutanoic acid with methanol in acetic acid give methyl (S)-methyl 2-(N-((2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)pentanamido)-3-methylbutanoate compound (1).Reaction of compound(1) with hydrazine hydrate resulted 3-methyl butane hydrazide derivatives (2). Treatmentof(2) with malic anhydride, phthalic anhydride ,succinic anhydride afford pyridiazine derivatives (3-5)and then with acetylacetone, ethylacetoacetate, afford a new derivatives pyrazole compound (6-8) and evaluation of biological activity for some of them. The identification of isolated and purified compounds are elucidated by 1HNMR, IR.

Clinical studies predict an increase in the mortality rate among patients with heart disease and diabetes in the world by 2020 because of the symptoms of high blood pressure that leads to aggravation of the cardiovascular disease. Any rise in the level of amino acid in the blood directly contributes to high blood pressure and symptoms of diabetes that are considered a significant exacerbation of the causes of cardiovascular disease. Controversy still holds about the direct and indirect relationship between amino acids and cardiovascular disease (heart attack) and type II diabetes. Therefore, our study included verification of the relationship between amino acid concentration and the symptoms of heart attacks and diabetes type II. Our research was based on a study of 50 cases of patients of both sexes who suffer from heart disease and Type II diabetes, in addition to 25 healthy persons of 25-45 years of age as a group control. Cases were randomly adopted from outpatient clinics in Tikrit Teaching Hospital. Reliable measurements of amino acid levels in the blood serum of people with stroke, heart attack and diabetes were done by using Eliza technique. They were compared with the approved standard controls. A sharp increase in the concentrations of homocysteine, triglycerides and cholesterol has been observed at the level of statistical significance (p ˂ 0.01) in patients who suffer from stroke, heart disease and diabetes type II compared with the healthy group. Whereas, a different relationship has been observed with folic acid and vitamin B12. The concentration of folic acid at the level of statistical significance (p ˂ 0.01) and the concentration of vitamin B12 at the level of statistical significance (p ˂ 0.05) have decreased in patients with stroke, heart disease, diabetes type II compared with the healthy group.

The aim of this study was to evaluate the relationship between fasting insulin levels and obesity adults, who do not suffer from chronic diseases and evaluate insulin resistance by HOMA-IR in the same groups. This study was performed in AL-Qasim green university / College of Agriculture/ Laboratory bio-technology with department of nutrition at the Murjan teaching hospital / in Babylon province/Iraq, for the period from June 2015 to January 2016. This study included 89 (100%) were patients with obesity 52 (58.43 %) and 37(41.57%) were control for age range from (19-40) years. This study was found significant association(P ≤ 0.05) between obese and control regarding the age (OR 7.46, CI (2.51-22.18)), gender (OR 3.16, CI (1.28-7.78)), WC (Fisher P≤ 0.05), presence of history of previous obesity (OR 2.85, CI (1.19-6.82)), suffering from Psychosocial stress (OR 0.25, CI (0.10-0.63)) and eating more (OR 0.04, CI (0.01-0.13)) while there was no significant association (P ≥0.05) in exercise daily activity (OR 2.19, CI (0.89-5.33)). This study shows there was significant mean differences (P≤ 0.05) of age, body mass index(Kg/M2), waist circumference(cm) and FBG (mmol/L) between control with obese and in FBG (mmol/L) for both gender. While there were no significant mean differences (P ≥0.05) of age, body mass index(Kg/M2), waist circumference(cm), insulin(ng/mL), HOMA-IR and TG (mmol/L) between obese and control groups for both gender. This study also shows that the significant mean differences (P≤ 0.05 ) in obese group in levels of FBG (mmol/L), HOMA-IR and TG (mmol/L) at the three class of obesity in obese group, While there was no significant mean differences (P ≥0.05) differences in levels of Insulin(ng/mL), despite the high level at class III of obesity. Correlation analysis showed there was positive correlation between BMI with insulin fasting for the obese group. This study of Correlation analysis also showed positive correlation between BMI and insulin fasting and between BMI with HOMA-IR for female in obese group.

A new organic ligand (Chalcone-azo ligand), (2E)-1-(4-((4,5-diphenyl-1H-imidazol-2-yl)diazenyl)phenyl)-3-(2-hydroxyphenyl) prop-2-en-1-one (SACAI) with its divalent (Co, Ni and Cu) complexes were synthesized. The azo-derivative was prepared via the preparation of amino chalcone first, then diazoating of this amine and coupling with (4, 5-diphenylimidazole) component. Three transition metal ion complexes were prepared from this legend, after the determination of (M: L) ratio beyond the ultraviolet-visible studies of the (ligand-ion) mixtures. The M: L ratios for all complexes were (1:2). The amino-chalcone, new ligand (SACAI) and its complexes were identified with the available techniques such (Mass spectroscopy for the ligand, elementary analysis, Atomic Absorption, UV-Visible spectroscopy, F.T.I.R spectroscopy), electrical molar conductivity and Magnetic susceptibility for the solid complexes. From the results obtained, we can suggest the non-ionic octahedral geometry for all complexes. The new ligand acting as a bidentate chelating ligand that coordinating from the N3 imidazole atom and the far azo heterocyclic ring nitrogen atom.