Iraqi National Journal Of Chemistry

The study aimed to evaluate Glucagon-Like Peptide-1 levels in Polycystic ovary
syndrome(PCOS) infertile female with Diabetes Mellitus (DM) and compare the
results with control group , also , to find the correlation for GLP-1 with Luteinizing
hormone(LH), Follicle stimulating hormone(FSH) and LH/FSH ratio that may be
used in prediction atherosclerosis in these patients. The study included nineteen
women with age ranged(30-40) years and BMI ranged between (30-35) Kg/m2.
Subjects were divided into two groups: group(1) consist of (45)females as a healthy
control and group(2) consist of (45) infertile females with PCOS and DM as
complication . Fasting serum glucose was determined by using commercial kits
(Biolabo SA-France); LH , FSH , prolactin were determined by ELISA, fasting serum
insulin was determined by using ELISA kit(DRG-Germany).Insulin-resistance(IR)
calculated by (HOMA-IR) . FSH , LH , LH/FSH ratio and prolactin levels for all
studied groups were measured . A highly significant elevation in prolactin, LH and
LH/FSH ratio was found when G1 comparing with G2 . While significant reduction
seen in FSH levels in G2 comparing to G1 . A high significant elevation in Fasting
blood glucose , % HbA1C levels in patients group when comparing to healthy
control . Results revealed a highly significant elevation in insulin,HOMA-IR and
glucagon, while there are a significant reduction in GLP-1levels. There is significant
positive correlation was found in GLP-1 levels with (FSH) in G1 ,while a significant
negative correlation was observed in levels of GLP-1 and (FSH) inG2. A significant
negative correlation was found in GLP-1 levels and (LH) in G1 ,while a significant positive correlation was found in GLP-1 levels with (LH) in G2 . Results illustrated
significant negative correlation was seen in levels of GLP-1 with LH/FSH ratio in
G1,while there are a significant positive correlation in GLP-1 levels with LH/FSH
ratio in G2 . The conclusion could be drown from this study that GLP-1 has a
correlation with LH , FSH which may be considered as a marker in PCOS patients
with DM that prone to atherosclerosis .

N-[5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl]benzenesulfonamide
compounds
are
important due to have multi biological activity. In our present study sulpha
compound derivative have been synthesized and identify by using the spectral
methods of 1HNMR , Mass ,IR, and C,H,N. The physical and chemical data
suggested molecular and structural formula of synthesized compound.

Back ground Interleukin-6 (IL-6) is biologically active small protein
molecules known as cytokines .These cytokines are produced by
leukocytes, adipocytes, and endothelial cells, and it is involved mainly in
inflammatory processes. IL-6 has a role in stimulating the immune
response as trigger to infection or trauma through the production of
acute-phase proteins that accompany the inflammatory process. IL-6
synthesized according to code from messenger RNA, so their production
in tissue in responce of inflammation are increased by the action of
increasing expression of its own specific messenger RNA and the
expression levels of the mRNAs were either up- or down-regulated by
adjacent focal infiltrating lymphoid cells according to the state of
periodontal in health and disease so the local concentration of cytokines
reflect the state of inflammatory process under control at nuclear level.
The aim of study is to evaluate the inflammatory cytokine that associated
the process of periodentitis
Methods: Salivary specimens were obtained from patients having
chronic periodentitis and healthy subject act as control group. The
assessment of IL6 concentrations were established by technique enzyme
linked immunoassay.Results: level of IL-6 in saliva sample after evaluation the result showed
statistically significant difference between patients and control .

In this study the adsorption of cefixime on Iraqi clay attapulgite.
Quantitative estimation of the drug adsorption has been done by utilizing the
technique of UV-Vis spectrophotometry at (λmax = 273 nm) at different
conditions of temperatures (25, 37 and 45˚C). It was found that, the
adsorption decrease with increase the temperature. Study effect of pH (3, 5,
7 and 9) on adsorption of drug on attapulgite and it was found that, the
optimum adsorption was achieved at (pH = 3). Study of clay weight of
attapulgite in the range of (0.1-1.5 g.) and it was found that, the adsorption
increase with increase of clay weight. Finally effect of ionic strength on
adsorption process was investigated using a range of NaCl solution (0.1-0.3
M) and it was found that, there was a decrease in adsorption efficiency over
attapulgite with increase of ionic strength. The results of adsorption isotherms
that were obtained in this study were fitted with Langmuir adsorption
isotherm.

A new Schiff base ligand has been synthesized from
condensed 6.Amino Penicillinic acid with Benzyldehyde , then it
mixed with number of the transition metal to form complexes.
The newly prepared Schiff base ligand and metal complexes have
been characterized by various techniques such as 1H NMR, 13C
NMR , UV/ Visible, FT IR , Mass spectral ,Magnetic moment, molar
conductance method , and it tested the effectiveness of inhibitory
compounds prepared against four types of bacteria S.aureus ,
pseudomonas aeruginosa , Streptococcus Facials and Proteus
Mirabils then it isolated from different classes of ulcerative
infections.

New pyrimidine derivatives comprising azo, schiff's bases,
chalcones, and chromene ring moieties were prepared.The newly
synthesized compounds have been established on the basis of
their m.p., TLC, FT-IR, UV-Vis ,¹H-NMR data and element analysis.
These compounds were screened for their antimicrobial and in
vitro antioxidant properties. The results of this investigation
revealed that these compounds are potent antimicrobial and
antioxidant agent