Tikrit Journal of Pharmaceutical Sciences

A total of 150 patients with asthma on salbutamol therapy were included in this study along with 90 apparently healthy adult person ( control group) were investigated for the measurements of serum sodium and potassium levels. All patients and controls were fasting when sampleds Sodium and potassium serum levels have been performed by using flame photometer. All patients showed a normal serum sodium (mean 139.8 mmol/L)while the majority (73.4%) of the patients showed hypokalemia (mean 3.1 mmol/L)when compared to control. This study showed that salbutamol have no deteriorated effect on sodium, while it may reduce potassium levels in the majority of patients.

One hundred mothers of children below two years of age were interviewed regarding some socioeconomic and health factors affecting breast-feeding in the area seived by IBN-AL-balady Hospital in Baghdad at august 200?. The study revealed that 57Yo of the mothers were exclusively breast-feeding their children insufficient milk was the most common mentioned reason (57.7%) for starting bottle feeding.A negative association was observed between breast -feeding and education of the mothers" Illiterate mothers were more likely to breast;-feed their infants (70%) than educated mothers (57.1 %) .More governmental and social support is needed to promote and protect breast feeding in our society.

The morbidity and mortality of diabetus mellitus - related complications can be greatly reduced by constantly checking patients blood sugar ( self - monitoring or HbAlc testing). Some patients can not receive this comprehensive diabetic care. This study try to ciarify the relation between some inflammatory markers and sugar control in diabetic patients. The study includes 50 patients ( 18 males and.32 females ) from samarra city . All were reviewed with history, thorough examination, and investigations. Out of 50 patients with diabetes, 39 had high blood sugar, 40 had high ESR, 9 had increase in both blood sugar and ESR, 17 had abnormal (high) blood sugar and albuminuria, 17 had high ESR and albuminuria. Other causes of high ESR should be excluded such as rheumatoid arthritis, anemia, haematological diseases and infection like brucellosis .

The current investigation was designed to seek for the relationship of malondialdehyde (MDA) with the parameters of serum lipid profile in diabetes mellitus. To achieve this purpose, 55 diabetics (l I IDDM patients and 44 NIDDM patients) and 25 age matched healthy subjects were enrolled. lt was found that significant (P<0.001) elevations of MDA, S.Tc, S.Tg, LDl-cholesterol and VLDLtriglycerides in both types of diabetics when compared with those of the healthy individuals.The correlation analysis established marked conelation of MDA with S.Tc, STg, and LDl-cholesterol levels in two types of diabetics while VLDLtriglycerides demonstrated obvious correlation with MDA in IDDM. The result pointed out the interrelation ships of MDA with serum lipid profile in diabetes mellitus.

The research is concemed with studying of activity of some antibiotics (Tetracycline, Gentamycine and streptomycine) and their complexes with some metal (Ca, Mg ,Fe) were been studied by electric conductivity, ultraviolet spectroscopy (UV) to compare the biological effects of these complexes with the physiochemical methods for determination of this complexes such as association constant Ka, equivalente conductance (A) at infinit dilution and the distance between ions in solution R at the best fit values of standard deviation (c'A) which are caloulated for each antibiotic and their complexes with the absorbance of these complexes in neutral medium at room temperature.

This research deals with spectrophotometric method for determination of Triprolidine Hydrochloride drug (TPH) using two different oxidizing agents; Potassium permanganate and Potassium dichromate .The analytical results obtained are as follow :1- The alkaline media (NaOH): Potassium permanganate gives green solution which gives spectrum with amaximum absorption at 612nm its found that optimum conc. for alkaline solution is 1.2X10 'M and 1X10>M for Potassium permanganate within 10 minutes oxidizing time. The statistical and other analytical results for drug concentration range (1-12) ppm are as follows: Correlation coefficient r = 0.9989 , molar absorption coefficient 26993 L/mol.cm and sandel’s sensitivity is 0.0122pg/cm? at Apa =612nm. This method is applied for the determination of TPH in pharmaceutical preparations with percentage recovery not less than 96.22 %. 2-The acidic media (HCI): Potassium dichromate gives yellow solution with amaximum absorption at 350 nm the optimum conc for acidic solution is 1X10% M and 1.5X10°M for Potassium dichromate duringl5 minutes oxidizing time. The statistical and other analytical results for drug concentration range (1-12) ppm are as follows: Correlation coefficient r = 0.9969, molar absorption coefficient 38559.5 L/mol.cm and sandel’s sensitivity is 0. 0086pg/cm? at Amax =350nm This method is applied for the determination of TPH in pharmaceutical preparations with percentage recovery not less than 94.66%.

Psoriasis is anon-infectious,chronic disease of the skin. Arthritis associated in various age groups. This study used to evaluates difference between juvenile and adult psoriatic arthropathy at Mosul city, Mosul teaching hospital during the period of 1 st Jan. till 3o1h of June 2002. 115 patients with psoriasis participated in this study, 80 of them more than 16 years old consist of 41.9% male and 58.1% female with mean age ±SD = 38.6 ± 15.3, while other 35 patients less than 16 years old consist of 60% male and 40% female with mean age± SD = 9.2 (4-16). Arthritis associated, followed or antedated skin lesions, in 20% of them nails were affected, only 20% of juvenile patients and about 80.5% of adult patients were complaint of morning stiffness and only I 0.5% of adult patients developed ocular involvements in form of iritis. Family association of psoriasis and or psoriatic arthritis were presents in both juvenile and adult patients with psoriatic arthritis.

To assess serum level of immunoglobulins (IgG, IgA, IgM) in children with acute bacterial meningitis before therapy and at the end of intensive antibiotic therapy and in COMparison 1 heallity age aiid scx mittchicd vonirsls. Out of 37 vases adinived ta Thi-Als Atheer pediatric hospital (Mosul city) between January 2005 and July 2007, 29 cases proved to be a case of Haemophilus influenzae meningitis. Two died during the follow up period and 27 completed the study. Also included 30 apparently healthy age and sex matched subjects taken as control group. Initially from both group (patients and control) Sml venous blood samples were taken and assay of serum immunoglobulin (IgG, IgA, IgM) were done by single radial immunodiffusion method using commercial kits. After two weeks of intensive antibiotic therapy another blood samples were taken from the patients and assay of serum immunoglobulin levels were done using the same method and the same commercial kits. Initially before therapy there was a significant reduction in all immunoglobulin levels (IgG, IgA, IgM) in children with acute bacterial meningitis in comparison to controls. After 2 weeks of intensive antibiotic therapy, there was no significant difference in the mean serum immunoglobulin levels between the patients and controls. Acute bacterial meningitis as a disease and the intensive antibiotic therapy do affect the humoral immune response as reflected by the serum immunoglobulin levels (IgG, IgA, IgM).

Considerable information are accumulated about normal composition of blood. i80) males and (50) females attended this study aged from 18-40 years to investigate the effect of season on some blood parameters. The samples of venous blood were collected at the October 2A07 b May 2008. All blood parameters hemoglobin (Hb), packed cell volume (PC.V.), red blood cells (RBCs), mean corpuscular volume (MCV), mean cell hemoglobin (MCH) of males and females were within normal range of healthy subjects and also MCHC mean cell hemoglobin concentration was normal. There were significant different differences between the male and female students. There was no significant effect of season on blood parameters. The pulmonary function test included the measurement of peak flow meter and respiratory volume. There are significant differences in the value of pulmonary function between male and female students.

This study has been performed to evaluate the role of antioxidants in the treatment of bronchial asthma in adult patients. The specific objectives of this study are to evaluate the therapeutic effect of antioxidants in the treatment of branchial asthma in adult patients and whether the proper supplementation of antioxidants decreases the exacerbation of asthmatic attack. This study was conducted during the period from February through December 2008. Eighty asthmatic patients were included in this study. The patients were classified into 2 groups; first group was treated with vitamin E (tablet of 400 units per day) for 2 months duration, and those include 40 patients (24 males and l6 females), they have been subdivided according to the severity into mild asthma (28 patients) and moderate asthma (12 patients), while the other group of patients was treated with vitamin E (tablet of 400 units per day) and selenium (tablet 100 pg two times daily after meal) for 2 rnonths, and those include 40 patients (27 males and 13 females), and they have been subdivided according to the severity into mild asthma (29 patients) and moderate asthma (11 patients). The results revealed a significant inerease in peak expiratory flow rate (560.25 liter/min)after treatment with vitamin E, than before treatment with vitamin E(524.5 liter/min), while a highly significant decrease in serum rnalclndialdehyde was recorded after treatment with vitamin E(2.98 nmollml) than before treatment with vitamin E (3.85 nmol/ml). There was significant increase in peak expiratory flow rate after treatment with vitamin E and selenium (567,25 liter/min) than before treatment (558.0 liter/rnin), serum rnalondialdehyde shows a highly significant decrease after treatment with vitamin E and selenium (1.60 nmol/ml) than befcrre treatment (3.67 nmollml). The results also reveals a clinical improvement in those patients who received vitamin E and seleniurn, because vitamin E and selenium are a better antioxidant than vitamin E alone, and this proved by a lower serum malondialdehyde level in patients who had been received vitamin E and selenium

The present study was designed to determine the calcium and phosphorus levels in patients (N=30) suffering form renal failure in (Al-Qadissia hospital- Tikrit city) and comparing with healthy volunteers. This method is based on using specific kits for these measurements to calculate the concentration of these two elements in (mg/di) in patients and healthy volunteers with (p< 0.05) and show good correlation between higher level of calcium and lower level of phosphorus in serum .