Abstract
BACK GROUND:
Measurement of protein excretion in a 24-hour urine collection has been the long-standing goldstandard but time consuming test for the quantitative evaluation of proteinuria induced by
preeclampsia. An alternative method is the measurement of protein- creatinine ratio in a spot urine
sample, which provides a more convenient and rapid method to assess protein excretion.
OBJECTIVE:
To assess the correlation between the spot urine protein- creatinine ratio and 24-hour urine protein
excretion in women with preeclampsia and to use the urine protein- creatinine ratio as alternative to
time-consuming 24-hour urine protein collection.
Study design: A cross sectional study.
Setting: Department of Obstetrics and Gynecology at Al-Yarmouk Teaching Hospital for a period
of one year from Jan. 2013 to Jan. 2014
PATIENTSAND METHODS:
Eighty three singleton pregnant women suffering from pre-eclampsia with gestational age between
28 to 39 weeks were selected to participate in the study. They were divided into two groups:
61pregnant women with mild to moderate pre-eclampsia and 22 with severe pre-eclampsia.These
women were prospectively studied for proteinuria. Urine protein- creatinine ratio was determined
in a spot mid-stream urine sample, and the amount of protein excretion was measured in 24-hour
urine collected on the subsequent day. The correlation between the two tests was assessed.
RESULTS :
Diagnostic value of protein/creatinine ratio was expressed in terms of specificity and
sensitivity.There was significant correlation between protein/ creatinine ratio in a single void urine
with 24 hr. urine collection for protein as the P value was (0.0001), The ROC curve analysis
showed an area under the curve of (0.879), indicating that the urine protein: creatinine ratio can
detect severe proteinuria at a cutoff point of 4.2 with a sensitivity of (81.8%) and specificity of
(85.2%).
CONCLUSION:
There is a significant correlation between the spot urine protein/ creatinine ratio and 24-hour urine
protein excretion in women with preeclampsia.
Measurement of protein excretion in a 24-hour urine collection has been the long-standing goldstandard but time consuming test for the quantitative evaluation of proteinuria induced by
preeclampsia. An alternative method is the measurement of protein- creatinine ratio in a spot urine
sample, which provides a more convenient and rapid method to assess protein excretion.
OBJECTIVE:
To assess the correlation between the spot urine protein- creatinine ratio and 24-hour urine protein
excretion in women with preeclampsia and to use the urine protein- creatinine ratio as alternative to
time-consuming 24-hour urine protein collection.
Study design: A cross sectional study.
Setting: Department of Obstetrics and Gynecology at Al-Yarmouk Teaching Hospital for a period
of one year from Jan. 2013 to Jan. 2014
PATIENTSAND METHODS:
Eighty three singleton pregnant women suffering from pre-eclampsia with gestational age between
28 to 39 weeks were selected to participate in the study. They were divided into two groups:
61pregnant women with mild to moderate pre-eclampsia and 22 with severe pre-eclampsia.These
women were prospectively studied for proteinuria. Urine protein- creatinine ratio was determined
in a spot mid-stream urine sample, and the amount of protein excretion was measured in 24-hour
urine collected on the subsequent day. The correlation between the two tests was assessed.
RESULTS :
Diagnostic value of protein/creatinine ratio was expressed in terms of specificity and
sensitivity.There was significant correlation between protein/ creatinine ratio in a single void urine
with 24 hr. urine collection for protein as the P value was (0.0001), The ROC curve analysis
showed an area under the curve of (0.879), indicating that the urine protein: creatinine ratio can
detect severe proteinuria at a cutoff point of 4.2 with a sensitivity of (81.8%) and specificity of
(85.2%).
CONCLUSION:
There is a significant correlation between the spot urine protein/ creatinine ratio and 24-hour urine
protein excretion in women with preeclampsia.
Keywords
creatinine ratio
dipstick
Preeclampsia
Protein