Al Mustansiriyah Journal of Pharmaceutical Sciences

This study was designed to evaluate the effects of an air-powder polishing system on
the hot cure acrylic denture base material, which was cured in the water bath and microwave
method, and comparing it with a conventional dental lathe polishing specimens.
Thirty samples were made from the hot cure acrylic resin denture base after being
cured in water bath and microwave oven; all samples are condition and then polished. The
samples were numbered and divided into two groups (according to the types of curing
method), each group consists of 15 specimens and sub divided into three subgroups: airflow
polishing in (30 sec.), airflow polishing in (10 sec.) and conventional dental lathe polishing in
(2 min.). The average surface roughnesses of the samples have been determined with using
the profilometer (surface roughness tester) before and after polishing procedures.
All samples were weighted by using the precision electronic balance before and after
polishing procedures to obtain the results. The statistical analysis of the results before
polishing procedures showed that there were no statistically significant difference in the
surface roughness and weight loss of the hot cure acrylic denture base material for both curing
methods, while after polishing treatment by conventional dental lathe polishing (2 min.) and
air-powder polishing (10 sec. and 30 sec.), the statistical analysis of the results showed that
there were a decrease in the surface roughness and weight loss of the hot cure acrylic resin in
the water bath method more than in the microwave method and the best result shown with 2
minutes pumice. The weight loss of the acrylic in the (10 seconds) group polished surfaces
was best for the (30 seconds) group when using an air-powder polishing system. So, it is
preferred when using this polishing technique especially on the microwave cure method and
the air-powder, to be used effectively to polish the acrylic denture base materials using a short
period time.
Keywords: Air-Powder Polishing System, acrylic denture base, water bath, microwave
curing

Sincethe aurora of civilization, urolithiasishasplagued humans. Defective drainage
due to urinary tract obstruction at the narrowest part (ureterovesical junction, ureteropelvic
junction, and near the pelvic brim) via stones will eventually cause the agonizing renal colic
pain. Therapeutic managements of urolithiasis to relief acute colic pain are the primary
objective. Non-steroidal anti-inflammatory drugs are the most commonly used drugs as
suggested by many studies. It is very important to consider side effects of the drugs used in
the treatment of colic pain.
In order to preserve renal function and to relief obstruction, medical expulsion therapy
are used for ureteral calculi as a conservative management. These medications will aid the
passage ureteral calculi, an area that currently seems to be a field for continuous
investigation.The Aim of this Study is to compare renal biomarkers before and after
Lithotripsy and to evaluate the effect of Tamsulosin on these biomarkers in patients with
ureteral stones.
We concluded that, there were significant differences in the clinical outcomes
obtained after using tamsulosinfor 14days in patients withureteral stones who underwent
lithotripsy compared with those patients who were not used tamsulosin; thelevels of KIM-1,
andserum ureawere decreased significantly (pvalue <0.05) while the levels of ALP and
serum sodium show an improvement when compared to patients who were not used
tamsulosin but it\'s results were statistically not significant.
Keywords:Ureteral stones, lithotripsy, tamsulosin.

New series of 2-Azetidinone (4a-4f) were synthesized, the structure of these new
derivativeswereconfirmed using spectral methods starting from Ketoprofen we preparedan amide
ester by using DCC and TEA in DCM, then converted tohydrazide by using hydrazine hydrate,
then a Schiff bases weresynthesizedusingdifferent aromatic aldehydesin ethanol, and the final
compounds wereobtainedby cyclocondensationusingchloroacetylechloride.
The synthesis of the designed compounds has been successfully achieved. Purity and
characterization were confirmed by determination of physical properties (melting points &Rf
values), FT-IR spectroscopy and1H-NMRSp.
Keywords: Ketoprofen, Schiff base, 2-Azetidinone

Psoriasis is a chronic, autoimmune skin disease with cutaneous manifestations;
association of several factors including environmental, genetics and immunological
abnormalities with psoriasis is documented.
The acronym ANCA (Anti-Neutrophil Cytoplasmic Autoantibodies) is defined by an
accumulation of autoantibodies with specificity against different granulocytic, monocyte and
probably endothelial cytoplasmic antigens include (elastase, lactoferrin, lysozyme and
Cathpsin G ), are most commonly found in systemic vasculitis, necrotizing vasculitis and in
active generalized wegener\'s granulomatosis.
The objective of this study is to assess the anti-neutrophil antibody level (ANCA) as
inflammatory markers in patients with psoriasis with different degree of severity, correlate the
results with the degree of severity and compare the level of these antibodies with those of
control group.
This study was conducted from Feb. 2014 to Feb. 2015, blood samples were collected
from thirty two persons attending to Al-Karama Teaching Hospital, Baghdad Teaching
Hospital and private clinics, sixteen of them having psoriasislabelled as study groups and the
rest were free of the disease labelled as control group. The psoriatic patients were classified
into three groups according to the degree of severity of the disease as mild (four patients),
moderate (four patients) and sever (eight patients), the Psoriasis Area Severity Index (PASI)
were used to assess the severity of the disease. Thepatient’sgroup distributed as male (31.2%)
and female (62.8%), the serum level of ANCA antibody was measured in thepatient’s serum
of different degree of severity and in control group by using EnzymeLinked Immunosorbent
Assay technique (ELISA) in laboratory of Al-karama Teaching Hospital.
The results proved that the serum levels of ANCA in psoriatic patients were
significantly higher than that of control group in all degree of disease severity when ANOVA
test used to analyze the data, also the results reported that the level of anti- elastase and ant
lactoferrin were significantly higherin sever degree group of psoriatic patients than mild and
moderate degree groups (p≤0.05)when tested by LSD test, no significant difference was
noted between mild and moderate degree groups (p >0.05).
From that we can conclude that autoantibodies against neutrophil antigens are
generally associated with inflammatory psoriatic disorder; In addition, the autoantibodies
levels were related to the degree of severity of the disease especially antielastase and
antilactoferrin.
Keywords: Psoriasis, Anti-neutrophil Antibody ANCA, Autoimmune disease

Carbapenems,potent β-lactams antibiotics, were initially used as last-resort treatments
for severe Gram-negative bacteria such as Klebsiella pneumonia. These bacteria were
considered one of Enterbacteriaceae family associated with pneumonia and urinary tract
infection. In the current research, Carbapenemswere studied to identify the resistant K.
pneumoniaisolates and identifying the relation with some β-lactam resistance to avoid their
abuse for treatment.
A urine sample got from 80 infected female with chronic urinary tract infection, these
samples tested forK. pneumoniaand their carbapenemase production. The procedure was
based on disc diffusion and Landmane,t al.methods.
The results pointed out thatKlebsiellapneumoniaissignificantly present in patients
with urinary tract infection, the carbapenem resistance in disc diffusion and Landman
procedure was 100% and 88.5% formeropenem(MEM), while it was 57.2% and 65.4% for
imipenem(IPE), respectively. Regarding the carbapenem resistance in same isolate for both
(MEM and IPE), 69.23% (18/26) were coincidence and 30.77% (8/26) were mismatch in both
methods. In addition, the Landman procedure more accurate than disc diffusion for
carbapenem resistance and there is a strong association with Beta-lactam resistance.
It can be conclude that there is a high incidence of carbapenem resistance in local
isolates ofKlebsiella pneumonia. We recommend to use the supercarba media in diagnoses of
bacteria routine work because it is more specific along with disc diffusion method for patients
with urinary tract infection and the use of other treatments to decrease the level of resistance.
Keywords :Carbapenem resistance, Klebsiella pneumonia.