journal port science research

Fifty RA patients and 50 healthy individuals have been participated in this study. 196 M/R
polymorphism of TNFRII gene determined by PCR-RFLP, IL-37 level was measured by ELISA technique,
also RF, ACCP, CRP measured by ELISA technique. Our study shows an increase in IL-37 levels in patients
was suffered from rheumatoid arthritis relative to control group. (M=101.31+10.41) That shows major
differences between patients and controls (p<0.01) and increasing level of IL-37 correlate significantly with
increasing level of CRP (p<0.05). The frequencies of TNFRII gene polymorphism were significantly
correlate with the IL-37 level (p<0.01) in RA patients compared with control group. In conclusion, IL-37
increased in RA patients associated with disease development, also significantly associated with TNFRII
polymorphism.

Today's west an east scientists developed synthetic drugs but because of problems of the side
effects and high cost in addition to resistant developed which not happened in using natural drugs this push
the scientist in all over the world to look for new drugs from natural compounds. In Iraq. Since 1980 up
today we started a plan led by scientist in Chemistry, Pharmacology, Physician, Biology in all universities
& medical research centers and we started to develop a new method for extraction, isolation, ident cation of
active constituent and trying the active constituent biologically and pharmacologically in invitro and in vivo
on experimental animals. We started screening of more than thousand plants which indigenous in Iraq and
take the knowledge from folkloric physician and old information about these from ancient books and
references we found around two hundred promising plants we developed methods of extraction , isolation
using chromatography and trying to evaluate their efficacy .We managed to prepare drugs to treat warts
from Ficus Caria vitexin from Crataegus amorous, prostrating anew antihyperlipidemic drug from prosopis
fractal etc. A new method of isolation and identification by new phytochemical methods and new
experimental tool for each active constituent are as example how to separate alkaloids, cardiac glycosides
inotropic agents, polyphenoles etc. In addition to bacteriological, toxi-pathological methods then pass to
prepare anew natural drugs prepared with highly sophisticated methods and with highly efficiency which
may be better than synthetic drugs and more safe .

The aim of the study was to identify characteristic risk factors predisposing to coronavirus
disease 2019 (COVID-19) outbreak in a group of Iraqi patients in Baghdad City. In this study, we included
a total of 13411 persons who had been tested for COVID-19, supervised by Al-Razi Medical Center in
Baghdad City during the period from June 20 to November 13, 2020. Cases were tested and divided into
two groups according to the result of real-time RT-PCR test for COVID-19. A total of 1781 positive cases
were detected with confirmed COVID-19. Comorbidities in the study patients were identified as
hypertension, diabetes mellitus and respiratory disorders. Hypertension was the most common comorbidity
in COVID-19 patients followed by diabetes mellitus. The results of this study showed that patients with
comorbidities were significantly associated with positive RT-PCR results related to COVID-19. It was
concluded that understanding the comorbidities enhance defining patients with COVID-19 at higher risk.
Further research is needed to confirm and clarify the impact of the association of co-morbidities that
accompany COVID-19.

The aim of the study was to identify characteristic risk factors predisposing to coronavirus
disease 2019 (COVID-19) outbreak in a group of Iraqi patients in Baghdad City. In this study, we included
a total of 13411 persons who had been tested for COVID-19, supervised by Al-Razi Medical Center in
Baghdad City during the period from June 20 to November 13, 2020. Cases were tested and divided into
two groups according to the result of real-time RT-PCR test for COVID-19. A total of 1781 positive cases
were detected with confirmed COVID-19. Comorbidities in the study patients were identified as
hypertension, diabetes mellitus and respiratory disorders. Hypertension was the most common comorbidity
in COVID-19 patients followed by diabetes mellitus. The results of this study showed that patients with
comorbidities were significantly associated with positive RT-PCR results related to COVID-19. It was
concluded that understanding the comorbidities enhance defining patients with COVID-19 at higher risk.
Further research is needed to confirm and clarify the impact of the association of co-morbidities that
accompany COVID-19.

In the last few years there has been an exponential growth in the field of herbal medicine and
these drugs are gaining popularity both in developing and developed countries because of their natural origin
and less side effects. Many traditional medicines in use are derived from medicinal plants, minerals and
organic matter. The World Health Organization (WHO) has listed 21,000 plants, which are used for
medicinal purposes around the world. . The current review focuses on herbal drug preparations and plants
used in the treatment of different chronic dieses in the world. The use of Ayurvedic medicines is common
in both adults and children and is increasing in many areas of the world. This paper will discuss the benefits
with use of herbal medicines as Antipyretic, Antiulcer, Anti-diabetic and Anti-cancerous activity.

The aim of the study was to identify characteristic risk factors predisposing to coronavirus
disease 2019 (COVID-19) outbreak in a group of Iraqi patients in Baghdad City. In this study, we included
a total of 13411 persons who had been tested for COVID-19, supervised by Al-Razi Medical Center in
Baghdad City during the period from June 20 to November 13, 2020. Cases were tested and divided into
two groups according to the result of real-time RT-PCR test for COVID-19. A total of 1781 positive cases
were detected with confirmed COVID-19. Comorbidities in the study patients were identified as
hypertension, diabetes mellitus and respiratory disorders. Hypertension was the most common comorbidity
in COVID-19 patients followed by diabetes mellitus. The results of this study showed that patients with
comorbidities were significantly associated with positive RT-PCR results related to COVID-19. It was
concluded that understanding the comorbidities enhance defining patients with COVID-19 at higher risk.
Further research is needed to confirm and clarify the impact of the association of co-morbidities that
accompany COVID-19.

n this study 100 biopsies were taken from the endometrium of childbearing women (18-50
yrs. of age) suffering from abnormal vaginal bleeding from Jan 2019-Dec 2019. Endometrial Biopsy (EB)
is safe, an outpatient procedure, low cost, carries out without general anesthesia & the incidence of
hemorrhage, infection & uterine perforation are less common than with D&C. EB is an alternative to
dilatation & curette (D&C) for the evaluation of infertile & abnormal vaginal bleeding or dysmenorrheic
patients. There are two main groups of causes to irregular vaginal bleeding. 1. Organic disease (74% of the
cases), in this group there are obvious lesion such as, endometrial polyp, endometrial hyperplasia & chronic
endometritis. The most common cause was endometrial hyperplasia 48%, it is commonly seen during the
perimenopausal period (40-50yr). Less common causes include chronic endometritis 8%, hydatidiform mole
7%, and endometrial polyp 7%. 2. non-organic disease comprises 19% of all cases, anovulatory period 13%
or Luteal phase insufficiency 6%. They are commonly seen from age of 18-40yrs. 6% of the cases found to
have normal endometrium. 5 endometrial biopsies were inadequate & unsatisfactory for histopathological
interpretation. The aim of this study is to evaluate the usefulness & disadvantages of EB & to compare it
with the traditional method of endometrial curette.

The experiment based on 10 matured men samples collected randomly from Baghdad
Providence. The 10 samples divided into two groups, serum testosterone level of all 10 patient had been
done using Ichroma technique. the treated group administered 2.5ml of honeybee with 350mg of royal jelly
daily for (15day) while the second group stay as control group. After 15 days blood samples had been
collected and serum separated to made another testosterone test for both groups using same i-chroma
technique. The main Aim of this study is estimating the effect of royal jelly and honeybee as food on the
testosterone hormone level in men. The result show that there was significant increase in the testosterone
levels in treated group in comparison with control group, after experiment the result show significant
increase in testosterone levels (in samples number 1,2,3,4 and 5) as the following (23.2 n.mo/L, 16.6 n.mo/L,
17.7 n.mo/L, 10.1 n.mo/L and 29.7 n.mo /L respectively. The study concluded that, short term treatment of
royal jelly in combined with honey bee increasing the level of blood testosterone hormone in men in
different ages significantly. The study either concluded that we can used honeybee and royal jelly as natural
treatment of low testosterone level in men.

Vitexin was isolated and identified from pods of prosopis farcta (Iraqi endogenous). In vitro
and in vivo cardiovascular actions of vitexin were studied. Vitexin produced positive inotropic effect which
was not related to B1 adrenergic receptor activation. Vitexin has a vasodilator activity and it could reverse
thevasoconstrictor response of isolated pulmonary artery to potassium chloride and phenylphrine. Vitexin
has produced a significant increase in ejection fraction in volunteers with mild heart failure. Also, vitexin
has produced a significant increase in urinary flow and urinary sodium and potassium excretions in healthy
and mild hypertensive volunteers, it’s significantly reduced mean arterial blood pressure of the mild
hypertensive volunteers. The positive inotropic effect of vitexin is most properly related to the inhibition of
phosphodiesterase enzyme by vitexin. The vasodilator activities of vitexin could be mostly associated to the
increase in cGMP (attributed to phosphodiesterase inhibitory effect of vitexin) and the activation of K+-
channels. The diuretic effects of vitexin could be attributed to the inhibition of Na-Cl symporter system in
the renal distal tubule. The most likely mechanisms of action of vitexin as a hypotensive compound are
through its vasodilator and diuretic effects. So, this agent could be a best new antihypertensive drug
compared with present antihypertensive drugs which are in the market now. In addition to that vitexin can
be used in heart failure as cardiotonic drug.

Background and objective: Recent clinical trials have shown that metformin improves clinical
cardiovascular outcome in type-2 diabetic patients independently of its insulin-sensitizing effect. This study
was sought to evaluate the potential cardioprotective effects of metformin on isoproterenol-induced cardiac
stress in diabetic and non-diabetic rats. Materials and Methods: Diabetes was induced by using streptozocin
(60 mg/kg, i.p.) while non-diabetic rats received saline. Rats in both experimental groups were then
randomized to receive different doses of metformin (75, 150, 300 mg/kg i.p.) for 6 weeks. Cardiac stress
was induced by isoproterenol (150 mg/kg i.p.) for two successive days. Specific biomarkers of tissue injury,
namely brain natriuretic peptide (BNP), cardiac troponin-T (cTn-T), matrix metalloproteinase (MMP),
tissue necrotic factor-α (TNF), were assessed. Data were analysed using one-way ANOVA followed by
Newman Keuls post hoc test Results: The results showed that metformin significantly limited isoproterenolinduced
myocardial injury in both diabetic and non-diabetic rats. Metformin significantly decreased the
elevated serum levels of brain natriuretic peptide (BNP), matrix metalloproteinase (MMP), cardiac troponin
t (cTn-T) which was induced by isoproterenol. It also limited expression of tissue necrotic factor-α (TNF-
α) following the cardiac injury in diabetic and non-diabetic rats.