Abstract
The kinetic study of drug release is an essential requirement to examine the ability of the drug formulation to
modulate the typical drug release profile. In the present work, the Weibull model and other traditional drug
release models are selected to investigate the release of tablets prepared using different drying techniques in a
simulated abdominal solution. These tablets are prepared using electromagnetic microwave irradiation tablet
(MVT), convective drying tablet (CVT), freeze drying tablet (FRT), vacuum drying tablet (VAT), and without any
drying process tablet (NDT). This study aims to compare Weibull models with other conventional drug release
models in inspecting the kinetics of drug release in all tablets. These models are Zero-Order, Higuchi, First-Order,
Hixson-Crowell, and Korsmeyer-Peppas. This work delves into the best kinetic model that defines the tablets’
release mechanisms, including the new multicomponent tablets (MVT), to ensure their release is in appropriate
behavior. The results show that the Weibull model is the best model to present the release profile of all tablets
except for MVT and VAT, while Higuchi is the optimal model for. Among the conventional models, Higuchi,
Korsmeyer-Peppas, and Hixon-Crowell are the best conventional models to fit all types of tablets. Based on the
Weibull model factor, non-Fickian diffusion is the dominant release mechanism for NDT and VAT. Although
Fick diffusion controls the drug release mechanism of FTR, CVT, and MVT tablets. Additionally, three modified
models were created and found to be more convenient to denote the release of the formulated tablets with very
high accuracy
modulate the typical drug release profile. In the present work, the Weibull model and other traditional drug
release models are selected to investigate the release of tablets prepared using different drying techniques in a
simulated abdominal solution. These tablets are prepared using electromagnetic microwave irradiation tablet
(MVT), convective drying tablet (CVT), freeze drying tablet (FRT), vacuum drying tablet (VAT), and without any
drying process tablet (NDT). This study aims to compare Weibull models with other conventional drug release
models in inspecting the kinetics of drug release in all tablets. These models are Zero-Order, Higuchi, First-Order,
Hixson-Crowell, and Korsmeyer-Peppas. This work delves into the best kinetic model that defines the tablets’
release mechanisms, including the new multicomponent tablets (MVT), to ensure their release is in appropriate
behavior. The results show that the Weibull model is the best model to present the release profile of all tablets
except for MVT and VAT, while Higuchi is the optimal model for. Among the conventional models, Higuchi,
Korsmeyer-Peppas, and Hixon-Crowell are the best conventional models to fit all types of tablets. Based on the
Weibull model factor, non-Fickian diffusion is the dominant release mechanism for NDT and VAT. Although
Fick diffusion controls the drug release mechanism of FTR, CVT, and MVT tablets. Additionally, three modified
models were created and found to be more convenient to denote the release of the formulated tablets with very
high accuracy
Keywords
drug release
Erosio
Fickian diffusion
kinetics
Korsemeyer-Pepparug
modeling
Weibull