Abstract
Background: Several benefits were imputed to ketamine such as its analgesic, amnesic effects,
maintenance of muscle tension, as well as protection for airway re-flexes and spontaneous respiration.
Rationale: alteration in the hemodynamic status of the population under- went intravenous induction of
anesthesia is a common complication especially in propofol usage, where significant reduction in blood
pressure had been noticed, also assessment of ketamine on cardiac function has not well described.
Aim: to evaluate the hemodynamic parameters (blood pressure (B.P) heart rate (H.R)) in response to
propofol-ketamine mixture for adults and pediatric patients during different time intervals.
Methodology: the patients were divided into two age groups; group A: twenty five (25) Patients who
received propofol 2 mg/kg plus ketamine 0.3 mg/kg I.V, and group B: twenty five (25) patients received
propofol plus ketamine (using syringe mixture of 5 mg/ml propofol & 5 mg/ml ketamine) I.V. on
hemodynamic changes; heart rate (H.R) and blood pressure(B.P) which monitored and recorded at
different time intervals with respect of using other drugs like opioid analgesia.
Result: H.R of pediatric group was decreases un-markedly at induction and after 1min. and
5min, after induction. While the H.R of adult group unchanged at induction but decrease after 1min. and
5min. after induction but unremarked, the means of different age group heart rate where higher among
pediatric age group, regarding the blood pressure means, whether systolic or diastolic were unchanged at
different occasions.
Conclusion: the propofol Ketamine is an affective safe inductive agent, low injectable pain incidence
and with a rapid onset of action, so producing preferable hemodynamic stability.
maintenance of muscle tension, as well as protection for airway re-flexes and spontaneous respiration.
Rationale: alteration in the hemodynamic status of the population under- went intravenous induction of
anesthesia is a common complication especially in propofol usage, where significant reduction in blood
pressure had been noticed, also assessment of ketamine on cardiac function has not well described.
Aim: to evaluate the hemodynamic parameters (blood pressure (B.P) heart rate (H.R)) in response to
propofol-ketamine mixture for adults and pediatric patients during different time intervals.
Methodology: the patients were divided into two age groups; group A: twenty five (25) Patients who
received propofol 2 mg/kg plus ketamine 0.3 mg/kg I.V, and group B: twenty five (25) patients received
propofol plus ketamine (using syringe mixture of 5 mg/ml propofol & 5 mg/ml ketamine) I.V. on
hemodynamic changes; heart rate (H.R) and blood pressure(B.P) which monitored and recorded at
different time intervals with respect of using other drugs like opioid analgesia.
Result: H.R of pediatric group was decreases un-markedly at induction and after 1min. and
5min, after induction. While the H.R of adult group unchanged at induction but decrease after 1min. and
5min. after induction but unremarked, the means of different age group heart rate where higher among
pediatric age group, regarding the blood pressure means, whether systolic or diastolic were unchanged at
different occasions.
Conclusion: the propofol Ketamine is an affective safe inductive agent, low injectable pain incidence
and with a rapid onset of action, so producing preferable hemodynamic stability.
Keywords
Adult
hemodynamic parameters.
ketamine
PEDIATRIC
Propofol