Abstract
The term \"endocrine disorders\" refers to a collection of conditions that are caused by issues that occur in a portion of the endocrine system.It is possible for these illnesses to manifest themselves when the endocrine system creates an excessive amount or an insufficient amount of a hormone, or when the body does not react appropriately to the hormone.It is the purpose of this study to investigate the impact that endocrine abnormalities have on the spleens of both male and female laboratory rats.The rats, totaling twenty-four, were divided into three groups.(G 1), which consisted of eight rats (four males and four females), a normal saline solution was administered to them for a period of twenty-one days.) (G 2), which consisted of eight male rats, metoclopramide was administered intraperitoneally at a dose of 0.6 mg ø kg on a daily basis for a period of 21 days in order to induce hyperprolactinemia.(G 3), which consisted of eight female rats, metoclopramid was administered intraperitoneally at a dose of 0.6 mg ø kg. This was done in order to induce hyperprolactinemia for a period of 21 days. Following the conclusion of the trial, which lasted for 21 days, a number of blod parameters were evaluated, and the proportion of the hormone prolactin was evaluated.Subsequent to the resection of the spleen, the three groups were separated into their respective groups.Hematoxylin, eosin, and masson stain were used throughout the process of sectioning and staining the tissue. the study demonstrated a noteworthy rise (p<0.05) in the concentration of the hormone prolactin among the male and female group as compared to the control group.Upon histological inspection of the spleen, it was observed that there was a discernible alteration. It is important to note that the white pulp increased region covered around fifty percent of the spleen area in comparison to the red pulp area.The germi centre of the secondary and lymph follicle was observed; however, as compared to the control, we saw that the white pulp region was reduced. Furthermore, the secondary follicle, which is the active follice, was not observed.It is concluded from this that endocrine disorder have a clear effect on the tissue immune status of the spleen through the changes shown in the results of the current study.