Abstract
In order to study or evaluate the toxic effect of alcohol in mice and the role of vitamin C as a protective factor in this toxicity, a group of mice was given alcohol alone .Another second group was given alcohol with vitamin C for 90 days, and the third group represent the control group.Histopathological changes were showed hydropic degeneration and vacuolation with enlargement of the hepatocyte and then progress to fatty change.in addition there is necrotizing changes which being widely shown with the time of treatment,over a wide area at 90 days.These changes accompanied with inflammation which started after 2 weeks of experiment which characterized by a slight infiltration and then progress of lymphoid follicles in the parenchyma of the liver and cuffing of congested blood vessels. Also there is infiltration of fibroblast with increase activity of hepatocyte division.The second group of alcohol with vitamin C showed less severity changes than the first group which treated with alcohol only.