Abstract
Osteoarthritis (OA) is the most common articular disease world wide. It is
the result of both mechanical and biological events that destabilize the normal
coupling of degeneration synthesis of articular cartilage and subchondral bone.
Rheumatologist often routinely order tests for rheumatoid factor and
erythrocyte sedimentation rate (ESR) for all patients with joint complaints as
well as C - reactive protein (CRP) as a laboratory marker important in the
assessment of inflammation. Anti malarial drugs are used for treatment of many
rheumatic diseases. Chloroquine phosphate (CQP) was used previously as a
disease modifying anti rheumatic drug and in this study its effect appears
through decreasing the measurement of erythrocyte sedimentation rate (ESR)
and C-reactive protein (CRP) in knee osteoarthritic patients (KOA).
Abbreviation: HCQ, hydroxy chloroquine; CQ, chloroquine; DMARD, disease
modifying anti rheumatic drug; APP, acute phase protein; ACR, American
College of Rheumatology; RA, rheumatoid arthritis; SLE, systemic lupus
erythematosus; RF, rheumatoid factor.
the result of both mechanical and biological events that destabilize the normal
coupling of degeneration synthesis of articular cartilage and subchondral bone.
Rheumatologist often routinely order tests for rheumatoid factor and
erythrocyte sedimentation rate (ESR) for all patients with joint complaints as
well as C - reactive protein (CRP) as a laboratory marker important in the
assessment of inflammation. Anti malarial drugs are used for treatment of many
rheumatic diseases. Chloroquine phosphate (CQP) was used previously as a
disease modifying anti rheumatic drug and in this study its effect appears
through decreasing the measurement of erythrocyte sedimentation rate (ESR)
and C-reactive protein (CRP) in knee osteoarthritic patients (KOA).
Abbreviation: HCQ, hydroxy chloroquine; CQ, chloroquine; DMARD, disease
modifying anti rheumatic drug; APP, acute phase protein; ACR, American
College of Rheumatology; RA, rheumatoid arthritis; SLE, systemic lupus
erythematosus; RF, rheumatoid factor.