Abstract
The present study was conducted to know the effect of alcoholic extract of Nerium oleander leafs on some biochemical parameters as well as the histological changes in liver and kidney in male albino rats. Twenty mature albino rats were randomly divided one word groups: control group and treatment group. Control group was treated with drinking water for (6 weeks), while treatment group was treated with 4 mg/kg B.W of alcoholic extract of Nerium oleander leafs. Blood samples were collected every 3 weeks to make biochemical parameters. The results showed significant decrease (P<0.05) in Total protein , albumin and significant increase (P<0.05) in amino transmission enzymes concentration (AST and ALT) , urine and keratinin concentration in treatment group compared with control group. The study reveals high toxic effect of plant on all body tissues.