Abstract
The random uses of androgenic anabolic steroids such as dianabol (Alpha pharma)
especially among young people and adolescent could have harmful effects on health
.The aim of this study is to investigate the possible harmful effects of oral
administration of dianabol on the histology and hormones levels of the thyroid gland
in female rats. The study was carried out in the animal house ( College of
veterinaryMedicine / University of Al-Qasim Green . Twenty four female rats
(Rattus rattus ) were divided into 4 groups , three groups were given dianabol orally
at the concentrations of (0.05 , 0.1 , 0.2) mg/kgvrespectively on daily basis for six
weeks , and the fourth group, served as a control group, was injected by (0.9%Nacl).
Thyroxine (T4), triiodothyronine(T3) and thyroid stimulating hormone (TSH) were
estimate, Histological study included the histopathological changes in thyroid gland
tissue. The results showed a significant increase (p< 0.05) in the levels of TSH, T4,
and T3 compared with the control group .This study also showed changes in the
thyroid tissue that included hyperplasia of thyroid follicles, colloid material in most
follicles, little or no increase in the size of follicles which suggest that increased dose
of dianabol leads to pathological (Physiological and histological) changes noticeable
in most of the studied criteria.
especially among young people and adolescent could have harmful effects on health
.The aim of this study is to investigate the possible harmful effects of oral
administration of dianabol on the histology and hormones levels of the thyroid gland
in female rats. The study was carried out in the animal house ( College of
veterinaryMedicine / University of Al-Qasim Green . Twenty four female rats
(Rattus rattus ) were divided into 4 groups , three groups were given dianabol orally
at the concentrations of (0.05 , 0.1 , 0.2) mg/kgvrespectively on daily basis for six
weeks , and the fourth group, served as a control group, was injected by (0.9%Nacl).
Thyroxine (T4), triiodothyronine(T3) and thyroid stimulating hormone (TSH) were
estimate, Histological study included the histopathological changes in thyroid gland
tissue. The results showed a significant increase (p< 0.05) in the levels of TSH, T4,
and T3 compared with the control group .This study also showed changes in the
thyroid tissue that included hyperplasia of thyroid follicles, colloid material in most
follicles, little or no increase in the size of follicles which suggest that increased dose
of dianabol leads to pathological (Physiological and histological) changes noticeable
in most of the studied criteria.
Keywords
dianabol
thyroid gland
TSH