Abstract
The present study was designated to estimate the histological effect after administration of cold watery
fenugreek seeds extract of the nephron in albino mice. This work was carried out on 40 healthy adult mice aging (6-8
months). The experimental animals was divided into four treated groups (A, B, C, D) and control group. Preparation the
watery fenugreek seeds extract for administration with (150 mg/g) of concentration. The experimental animals treated
with extract for different time periods as the following (15, 30, 45, 60 days). The histological results of the treated groups
show after the following time periods [A after(15) days, B after (30) days, C after (45) days and D after (60) days of
administration]. The histological results showed the nephrons composed of renal corpuscle, proximal convoluted tubules,
Henelʼs loop, and distal convoluted tubules, the current results appears that the renal corpuscle composed of tuft of tinny
capillaries glomerular surrounding by double layer called Bowmans capsule which contain between two layers occur
main space that called Bowmans space, so showed the mesangial cells occupied the spaces between the glomerular
capillaries. The glomerular capillaries had significant increase in diameter. The proximal convulated tubules, lined by
simple high cuboidal epithelial cells with more prominent brush border, the tubules characterized by significant increase
in diameter. The present study Henelʼs loop notification the epithelial layer of internal surface of lined with simple
squamous epithelial and acidophilic cytoplasm. The tissue section appears that the nephron composition characterized by
significant increase in diameter with increased the time periods of administration of extract for the treated groups which
showed exfoliated cells that aggregation in the lumen on tubular structures of the nephron. The extract have significant
effect on the depression of height the epithelial cells lining of the internal surface of the proximal, henel loop, and distal
convoluted tubules that associated with increased time of administration of extract which led to increase the glomerular
infiltration rate that led to increase the amount of infiltration inside the tubular structures of the nephron in addition to
increase the speed the infiltration flow .
fenugreek seeds extract of the nephron in albino mice. This work was carried out on 40 healthy adult mice aging (6-8
months). The experimental animals was divided into four treated groups (A, B, C, D) and control group. Preparation the
watery fenugreek seeds extract for administration with (150 mg/g) of concentration. The experimental animals treated
with extract for different time periods as the following (15, 30, 45, 60 days). The histological results of the treated groups
show after the following time periods [A after(15) days, B after (30) days, C after (45) days and D after (60) days of
administration]. The histological results showed the nephrons composed of renal corpuscle, proximal convoluted tubules,
Henelʼs loop, and distal convoluted tubules, the current results appears that the renal corpuscle composed of tuft of tinny
capillaries glomerular surrounding by double layer called Bowmans capsule which contain between two layers occur
main space that called Bowmans space, so showed the mesangial cells occupied the spaces between the glomerular
capillaries. The glomerular capillaries had significant increase in diameter. The proximal convulated tubules, lined by
simple high cuboidal epithelial cells with more prominent brush border, the tubules characterized by significant increase
in diameter. The present study Henelʼs loop notification the epithelial layer of internal surface of lined with simple
squamous epithelial and acidophilic cytoplasm. The tissue section appears that the nephron composition characterized by
significant increase in diameter with increased the time periods of administration of extract for the treated groups which
showed exfoliated cells that aggregation in the lumen on tubular structures of the nephron. The extract have significant
effect on the depression of height the epithelial cells lining of the internal surface of the proximal, henel loop, and distal
convoluted tubules that associated with increased time of administration of extract which led to increase the glomerular
infiltration rate that led to increase the amount of infiltration inside the tubular structures of the nephron in addition to
increase the speed the infiltration flow .