Abstract
Immunological profile of LADA is not so clear, so detection of chemokines is quite important to determine the extent and direction of immune responses.
Objective: the aim of the study is to clarify the levels of chemokines in diabetes mellitus type 2 patients and LADA patients and show their relation with diabetes complications.
Methodology: level of the chemokines CCL2, CCL3and CCL4 were estimated in 90 subjects (34 known LADA cases, 36 D.M.2 cases & 20 healthy control participants), participating patients were recruited from Diabetes outpatient clinic in AL-Hussein Teaching Hospital in Karbala from June, 2013 through January, 2014. A clinical questioner containing personal data, family history, type of diabetes, hemoglobin A1C( HA1C), body mass index (BMI), diabetes duration&
complications of diabetes was obtained from all patients. Statistical analysis done by using the statistical package for social sciences (SPSS) software for windows, data of all participants were entered and analyzed with appropriate statistical tests.
Results: significant high level of CCL2in LADA group compared to DM2, a positive correlation between CCL2 and duration of diabetes. Also CCL2 levels increased more with obese diabetic patients. .higher concentrations of CCL3 and CCL4 are associated with more complications in DM2 group.
Objective: the aim of the study is to clarify the levels of chemokines in diabetes mellitus type 2 patients and LADA patients and show their relation with diabetes complications.
Methodology: level of the chemokines CCL2, CCL3and CCL4 were estimated in 90 subjects (34 known LADA cases, 36 D.M.2 cases & 20 healthy control participants), participating patients were recruited from Diabetes outpatient clinic in AL-Hussein Teaching Hospital in Karbala from June, 2013 through January, 2014. A clinical questioner containing personal data, family history, type of diabetes, hemoglobin A1C( HA1C), body mass index (BMI), diabetes duration&
complications of diabetes was obtained from all patients. Statistical analysis done by using the statistical package for social sciences (SPSS) software for windows, data of all participants were entered and analyzed with appropriate statistical tests.
Results: significant high level of CCL2in LADA group compared to DM2, a positive correlation between CCL2 and duration of diabetes. Also CCL2 levels increased more with obese diabetic patients. .higher concentrations of CCL3 and CCL4 are associated with more complications in DM2 group.