Abstract
This study aimed to determine the toxic effects of melamine in some blood and biochemical parameters, in addition to evaluating the role that each of the enzymatic cofactors can play in reducing the toxic effects of melamine in male rats for a period of 30 days. A random sample of male white rats (40) was used in this study, divided randomly into four groups, the control group (C): was dosed with physiological saline NaCl at a concentration of 0.9% for 30 days and counted as the control group. The first treatment group ((T1):was dosed with melamine at a concentration of 50 mg/kg of body weight per day for 30 days. The second treatment group (T2):was dosed with coenzyme Q10 at a concentration of 10 mg/kg of body weight per day for 30 days. The third treatment group (T3): Melamine was dosed at a concentration of 50 mg/kg of body weight and coenzyme Q10 at a concentration of 10 mg/kg of body weight simultaneously daily for 30 days.After the end of the experiment, the following criteria were studied: Lipids (cholesterol, triglycerides, and high-density lipids) as well as Antioxidants and blood parameters, including (red blood cell count, hemoglobin concentration, and packed cell volume) in male rats.The results showed that dosing rats with melamine led to a significant decrease (P<0.05) in the number of RBC, Hb and PCV in (T1) compared with the control group.In contrast, the results showed a significant increase (P < 0.05) in the average ofRBC,Hb andPCV in animals of group (T3) compared with group (T1). The current results indicated that the treatment with melamine led to a significant increase (P<0.05) in the levels of total cholesterol, triglycerides, LDL and VLDL in the blood with a significant decrease in the level of HDL compared with the control group, on the other hand, the current results showed a significant decrease In the level of lipids andincrease in HDL in the blood of animals dosed Q10 with melamine compared with animals dosed only melamine. The results of the current study showed a significant decrease in the level of (GSH) and (CAT), accompanied by a significant increase in the level of (MDA) in the group (T1) when compared with the control group. In addition, the present results showed that decreased the level of MDA and increased the level of GSH and CAT compared to the animals given only melamine.
